摘要
目的应用病例对照研究方法,对临床前列腺增生（BPH）手术病例进行调查,以研究吸烟、体质指数与良性前列腺增生危险性之间的关系。方法病例组为2004～2006年施行良性前列腺增生手术,年龄在50～82岁的343名男性;对照组为与病例年龄相同的361名患其他疾病的男性。采用自行设计的调查表对住院期间研究对象进行调查,内容包括人口学特征、身体测量、生活方式（吸烟、膳食情况）、个体疾病既往史以及家族一级亲属前列腺疾病史等。采用多元回归模型测量各因素与BPH关系的比值比（OR）及其相应的95%CI。结果控制了年龄和体质指数后,每天吸烟1～29支与发生BPH的危险性无关,OR=0.97,95%CI=0.68～1.46,P〉0.05。但每天吸烟≥30支与不吸烟者比较,发生BPH的危险性增加,OR=1.32,95%CI=0.92～2.58,P〈0.01。超重者（BMI24.0～27.9）或肥胖者（BMI≥28）吸烟与发生BPH的危险性显著地增高,与不吸烟者比较分别为：OR=1.68,95%CI=1.32～3.67和OR=2.35,95%CI=1.83～4.16。结论只有现行吸烟≥30支/d的男性才与BPH呈正相关,超重和肥胖的男性吸烟发生临床BPH的危险性显著地升高。
Objective To examine the association between smoking, body mass index（BMI） and the risk of clinical benign prostatic byperplasia（BPH）, using a hospital-based for surgically treated BPH, case-control study. Methods Cases were men who bad surgically treated BPH between 2004 and 2006 （ n = 343）, 50 - 82 years old; noncases（controls） were men who bad the same age as cases（ n = 361） who admitted to the same hospital as cases for many different diseases not related prostatic conditions. The cases and controls were inerviewed during their hospital stay, using a self-designed questionnaire that included information on sociodemographic characteristics, antbropometric measures, lifestyle habits（including tobacco smoking and dietary consumption）, personal medical history, and family history of prostatism in first-degree relatives. Odds ratios（ORs） and corresponding 95 % confidence intervals of variables were estimated using unconditional multiple Logistic regression models. Results After controlling for age and BMI, moderate cigarette smoking was no related with surgically treated BPH（ 1-29 cigarette/day versus never smoking： OR = 0.97, 95 % confidence interval（ CI 0. 68 - 1.46 ; P trend 〉 0.05 ）, although current cigarette smoking was positively related to BPH surgery only among those who smoked 30 or more cigarettes/day （compared with never smokers： OR = 1.32, 95 % CI 0.92 - 2.58 ; P trend 〈 0.01 ）. Age-adjusted relative risks for surgically treated BPH in smokers versus nonsmokers stratified by BMI（obesity） were estimated. For men who were both overweight （BMI 24.0-27.9） and obesity（BMI≥28.0）, smoking was associated with a significantly increased risk for surgically treated BPH （compared with never smokers： OR = 1.68, 95 % CI 1.32 - 3.67 and OR = 2.35, 95 % CI 1.83 - 4.16 respectively）. Conclusion Current cigarette smoking was positively related to BPH surgery only among those who smoked 30 or more cigarettes/day. For men who were both overweight （ BMI 24.0 - 27.9 ） and boesity （ BMI ≥ 28.0 ）, smoking was associated with a significantly increased risk for surgically treated BPH.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2007年第7期796-797,共2页
Chinese Journal of Public Health
基金
辽宁省教育厅基金项目(991721591)
