摘要
背景与目的:上皮样肉瘤是一种组织起源尚不清楚的罕见软组织肉瘤。其生物学行为独特,容易发生局部复发、淋巴结扩散和/或远处转移。本研究旨在探讨上皮样肉瘤(Epithelioid sarcoma)的临床特点、诊断、治疗和预后。方法:对我院1990年1月至2005年12月间收治的14例上皮样肉瘤临床资料进行回顾性分析,并结合随访资料进行生存分析。全组14例均接受手术治疗。首次手术均在外院进行。再次手术11例在我院进行(9例行扩大切除术,2例行截肢术;4例同时行区域淋巴结清扫术),3例仍在外院行局部切除术或扩大切除术。术后9例接受辅助性治疗,其中单纯放疗6例,放疗+化疗3例。结果:全组在本院病理科复检确诊为上皮样肉瘤。12例(85.7%)出现肿瘤局部复发。4例(28.6%)发现区域淋巴结转移,9例术后3年内死亡。全组总的1、2、5、10年生存率为71.43%、55.56%、27.78%和13.89%。结论:上皮样肉瘤恶性程度并不很高,但局部复发率高,容易发生淋巴结和/或远处转移,预后不佳。广泛性切除或根治性切除合并预防性区域淋巴结清扫术是治疗上皮样肉瘤的有效手段。
BACKGROUND ＆ OBJECTIVE. Epithelioid sarcoma is a rare soft tissue sarcoma with a high propensity for aggressiveness, regional nodal spread, and distant metastases. This study was to investigate the clinical features, diagnosis, treatment, and prognosis of epithelioid sarcoma. METHODS： The clinical data of 14 patients with epithelioid sarcoma, admitted to our hospital from 1990 to 2005, were analyzed. All of the 14 patients received initial operations at other hospitals. Eleven patients received extensive excision （9 patients） or amputation （2 patients）, and 4 of them also received local lymph node dissection at our hospital; 3 patients received another local excision or extensive excision at other hospitals again. Nine patients received adjuvant radiotherapy and 3 of them also received adjuvant chemotherapy. RESULTS： Ait diagnoses of epithelioid sarcoma were confirmed by pathology. Of the 14 patients, 12 （85.7%） had local recurrence and 4 （28.6%） had local lymph node metastasis, 9 （64.3%） died within 3 years after initial operation. The overall 1-, 2-, 5-, 10-year survival rates were 71.43%, 55.56%, 27.78%, 13.89%, respectively. CONCLUSIONS. The prognosis of epithelioid sarcoma is poor because of a high propensity for local recurrence, node metastases, and distant metastases. Extensive excision or radical excision combined local lymph node dissection is effective for epithelioid sarcoma.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2007年第7期782-784,共3页
Chinese Journal of Cancer
关键词
上皮样肉瘤
治疗
预后
Epithelioid sarcoma
Treatment
Prognosis
