摘要
目的探讨金属基质蛋白酶(MMP)及P53蛋白在声门上喉癌表达及与颈淋巴结转移的关系。方法采用分子原位杂交和免疫组织化学方法对声门上喉癌癌组织中的MMP-9 mRNA及P53蛋白的表达进行检测。结果喉癌组织中MMP-9 mRNA及P53蛋白表达的阳性率分别为60.7%,64.3%,MMP-9 mRNA及P53阳性者淋巴转移率均高于阴性者(均为P<0.05),在声门上喉癌组织中,MMP-9 mRNA及P53其淋巴结转移率高于一项表达阳性者和两项均不表达者,差异均有统计学意义(P<0.05)。结论MMP-9 mRNA及P53蛋白的异常表达与声门上喉癌淋巴结转移过程密切相关,对判断预后有重要意义。
Objective To evaluate the result of expression of MMP-9 mRNA and P53 in supraglottic carcinoma. Methods MMP-9mRNA and P53 protein were detected by in situ hybridization and immunohistochemistry in supraglottic carcinoma tissues. Results In cancer tissues the positive expression rate of MMP-9 mRNA and P53 were 60.7% and 64.3% respectively. In tissues with positive expression of MMP-9mRNA and P53 protein, lymphatic metastasis rate were 88% and 83% respectively, significantly higher than tissues with negative expression （P 〈 0.05 ）. Conclusions The expression of MMP-9mRNA and P53 Protein in supraglottic carcinoma is associated with cancer lymphatic metastasis and is important in analyzing biological behavior and predicting the prognosis of supraglottic carcinoma.
出处
《实用全科医学》
2007年第7期590-591,共2页
Applied Journal Of General Practice
关键词
喉肿瘤
移行细胞肿瘤
金属蛋白类
Laryngeal neoplasms
Transitional cell carcinoma
Metalloprotei
