摘要
目的观察糖皮质激素吸入对哮喘儿童血清白细胞介素(IL-4)水平和肺功能的影响。方法采用ELISA法分别检测轻、中度哮喘急性发作期儿童(30例)吸入丙酸倍氯米松2周前后和健康对照组(25例)血清中IL-4水平,并同时测1 s用力呼气容积(FEV1)占预计值的百分比。结果急性发作期患儿治疗前IL-4值明显升高,与健康对照组比较差异有显著性(P<0.01);急性发作期及缓解期FEV1占预计值的百分比较健康对照组下降(P<0.01);急性发作期患儿治疗后IL-4水平下降,FEV1占预计值的百分比升高(P<0.01)。结论哮喘儿童急性发作期血清中IL-4水平升高,糖皮质激素可使其水平下降,并改善哮喘患儿肺功能。
Objective To observe the effects of inhaled glucocorticoid treatment on the levels of interleukin （IL -4 ） and the charges in pulmonary function in asthma Children. Methods ELISA method was used to observe the serum IL - 4 levers of the control 25 children and the 30 children with the light and moderate acute asthma who inhaled beclometasone dipropionate before and after the period of onset. Meanwhile the percentage of predicted value of FEV1 in ls was also detected. Results It exhibited a dramatic increase in the IL -4 value of the asthma children in the period of onset prior to treatment and there existed a significance （ P 〈 0.01 ） compared with those in the control group. The percentage of predicted value of FEV1 in the periods of onset decreased compared with the control group （P 〈 0.01 ）. The IL - 4 levels in the asthma children receiving treatment in the periods of onset obviously decreased and the percentage of predicted value of the FEV1 increased（P 〈 0.01 ）. Conclusion The serum level of IL - 4 in asthma children proved to be high Glucocorticoid can lead to the decrease of IL -4 level so as to improve the pulmonary function of the asthma children.
出处
《社区医学杂志》
2007年第07S期15-16,共2页
Journal Of Community Medicine
