摘要
长期全身或局部应用糖皮质激素可发生激素性白内障,激素性白内障作为后囊下白内障的一种类型,其组织形态学表现、临床特点等有其特殊性。有关激素性白内障的发病机制较复杂且不明,有多种假说,都不能很好地解释后囊下混浊的形成过程,因而在预防及治疗上无有效手段。一种新的观点认为,激素可能通过生长因子影响晶状体上皮细胞分化,导致激素性白内障形成,因此,研究生长因子对晶状体上皮细胞增殖和分化的影响,可能是研究激素性白内障发病机制一个新的方向。
Prolonged use of topical or systemic glucocorticoids resuits in the development of glueocorticoid-induced cataract （GIC）. Classified as a posterior subeapsular cataract, GIC exhibits its distinctiveness either in histology, morphology or clinical features. The mechanism of GIC is somewhat complex and obscure. Several mechanisms have been proposed. These mechanisms cannot convincingly explain the process of posterior subeapsular opacities. Therefore, no effective prevention or treatment for GIC is available. A novel approach is proposed in this paper, in which steroids affect the balance of ocular growth factors and subsequently inhibit the differentiation of lens epithelial cells （LECs）, which lead to the formation of GIC. Based on this hypothesis, a new approach for studying GIC mechanisms and investigating how growth factors affect the proliferation and differentiation of LECs is proposed.
出处
《眼视光学杂志》
2007年第4期281-285,共5页
Chinese Journal of Optometry & Ophthalmology
关键词
激素性白内障
后囊下混浊
晶体
上皮细胞
glucocorticoid induced cataract
posterior subcapsular opacities
lens
epithelial cells
