摘要
目的：探讨“参素酶合剂”对婴幼儿重症肺炎并充血性心力衰竭的治疗作用。方法：重症肺炎并充血性心力衰竭患儿１０２例，随机分为“参素酶合剂”治疗组５１例和对照组５１例。对照组采用常规综合治疗。治疗组在综合治疗的基础上，加用丹参注射液（出生～３个月者每次２ｍｌ，１～２岁者每次５ｍｌ）及维生素Ｃ（３００～５００ｍｇ·ｋｇ－１／ｄ）分别静滴；并加辅酶Ｑ１０１片口服，每日３次。结果：两组症状、体征恢复正常的时间均有显著性差异。两组呼吸频率、心率与肝脏肿大恢复正常的时间分别为１．５７２±０．１０１天比５．１７６±０．４３５天（Ｐ＜０．００１），１．７０９±０．１３７天比４．３００±０．３９６天（Ｐ＜０．００１）和１．５７７±０．１５６天比７．５００±０．７２５天（Ｐ＜０．００１）。两组治疗前后分别检测血清超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量，治疗前血清ＳＯＤ、ＭＤＡ含量无显著性差异，分别为８５．２５３±０．０２４ＮＵ／ｍｌ比８５．２８６±０．９８６ＮＵ／ｍｌ，８．４２１±０．０１４μｍｏｌ／Ｌ比７．７２０±０．０２１μｍｏｌ／Ｌ（Ｐ均＞０．０５）。治疗后ＳＯＤ、ＭＤＡ含量有显著性差异，分别为１２２．９３０±０．８?
Objective:To research the therapeutic effect of “shen su mei” mixture on infant severe pneumonia complicated by congestive heart failure(CHF).Methods:102 cases of infant severe pneumonia complicated by CHF were divided into two groups randomly:the treatment group(51 cases)and control group(51 cases).On the basis of general treatment,the patients of treatment group were used red sage root injection 2ml per day for newborn to three months old,5ml per day for three months to two years old,vitamin C 300￣500mg/kg per day,and one tablet of coenzyme Q 10 for three times per day.Results:There was obvious difference of restorative time in two groups.The restorative time of respiration rate,heart rate and hepatomegaly return to normal was 1 572±0 101 vs. 5 176±0 435 days ( P <0 001),1 709±0 137 vs. 4 300±0 396 days( P <0 001),1 577±0 156 vs. 7 500±0 725 days( P <0 001) respectively.The content of SOD and MDA as following:before treatment,they had no difference(85 253±0 024 vs. 85 286±0 986NU/ml,8 421±0 014 vs. 7 720±0 021μmol/L,all P >0 05) while after treatment,they had obvious difference 122 930±0 810 vs. 90 482±0 620NU/ml( P <0 01),5 060±0 140 vs. 6 850±0 760 μmol/L( P <0 01) .Conclusions:It suggested that “shen su mei” mixture is effective for protecting myocardium and treating infant severe pneumonia complicated by CHF.
基金
山东省济宁市科委科研课题
关键词
参素酶合剂
心力衰竭
心肌
药理学
shen su mei” mixture\ \ severe pneumonia\ \ congestive heart failure
