摘要
目的:观察依达拉奉对急性脑梗死患者血清IL-8、TNF-a、hs-CRP的影响。方法:采用随机对照试验,选择发病24小时内的急性脑梗死患者85例,随机分为治疗组和对照组,对照组40例按急性脑梗死常规方法治疗2周,治疗组45例在常规治疗基础上加用依达拉奉治疗2周,治疗前、治疗后3天、7天、14天检测患者血清IL-8、TNF-a、hs-CRP,比较它们的变化。结果:治疗组治疗后3天、7天、14天患者血清IL-8、TNF-a、hs-CRP明显下降,明显低于对照组。结论:依达拉奉能明显降低急性脑梗死患者血清IL-8、TNF-a、hs-CRP。
Objective： To study effects of edaravone on serum tumor necrosis factor-a, IL- 8 arid hs - CRP in patients with acute cerebral infarction. Method.. 85 patients of cerebral infarction were randomly divided and assigned to a therapy group and a control group. 40 patients in control group were treated by routine therapy of acute cerebral infarction two weeks. Another 45 patients in therapy group were treated by routine therapy of acute cerebral infarction, in addition to edaravone, two weeks. Recording the changes of serum tumor necrosis factor- a, IL - 8 and hs- CRP before treatment and after treatment 3d., 7d, 14d. Results： After treatment 3d., 7d, 14d, serum tumor necrosis factor- a, IL - 8 and hs - CRP decreased more dramatically, lower than that of the control group. Conclusion ： Edaravone can lower serum tumor necrosis factor- a, IL- 8 and hs- CRP in patients with acute cerebral infarction.
出处
《福州总医院学报》
2007年第1期75-77,共3页
Journal of Fuzhou General Hospital
