摘要
目的探讨宫内窘迫新生儿脐动脉血激活素A(ACT A)的变化及其临床意义。方法采用生物素-亲和素酶联免疫吸附试验检测40例正常妊娠对照组及35例胎儿宫内窘迫孕妇的新生儿脐动脉血ACT A水平,同时行脐动脉血血气分析。结果宫内窘迫孕妇组新生儿脐动脉血ACTA水平为(1235.89±178.78)ng/L,对照组为(627.28±75.24)ng/L,二组比较有显著性差异(P<0.05);脐动脉血血气分析,胎儿宫内窘迫组pH、p(O2)、碱剩余(BE)低于对照组,二组间比较有显著性差异(Pa<0.05),而p(CO2)高于对照组,二组间比较有显著性差异(P<0.05);胎儿宫内窘迫组新生儿脐动脉血ACTA水平与pH、p(O2)、BE呈负相关(r=-0.849,-0884,-0.817Pa<0.05);与脐动脉血p(CO2)呈显著正相关(r=0.835P<0.05)。结论胎儿宫内窘迫孕妇脐动脉血ACT A水平明显增加,且和脐动脉血气有明显的相关性,可作为一项新的临床指标预测胎儿宫内窘迫。
Objective To explore the change of activin A（ ACT A） in umbilical artery blood of newborns with fetal distress and its clinical significance. Methods Forty healthy pregnant women（ control group）and 35 pregnant women with fetal distress （experimental group）were collected. The levels of ACT A of umbilical artery blood in both groups were determined by a solid quantitative biotin - avidin system enzyme - linked immunosorbent assay（ BAS - ELISA）, umbilical artery blood gas were also measured. Results The level of ACT A of umbilical artery blood in fetal distress group was （ 1 235.89 ± 178.78 ） ng/L, and that in control group was （627.28 ± 75.24 ） ng/L, and the level of ACT A of umbilical artery blood in fetal distress group was significantly higher than that in control group （ P 〈 0.05 ）. The umbilical artery blood gas analysis： pH, p （ 02 ）, base execss （ BE ） in fetal distress group was lower than those in control group （ Pa 〈 0.05 ）. p （ CO2 ） in fetal distress group was higher than that in control group （ P 〈 0.05 ）. The negative correlation was found between ACT A and pH,p （ 02 ）, BE （ r = - 0. 849, - 0. 884, - 0. 817 Pa 〈 0.05 ）. The positive correlation was found between ACT A and p （ CO2 ） （ r = 0. 835 P 〈 0.05 ）. Conclusion The level of ACT A of umbilical artery blood increases in fetal distress group and correlates markedly with umbilical artery blood gas, suggesting that ACT A may reflect indi- rect fetal distress.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第14期1053-1054,1086,共3页
Journal of Applied Clinical Pediatrics
