摘要
目的:评价事件相关电位P_(300)和智能精神状态检查(MMSE)诊断轻微型肝性脑病(MHE)的价值.方法:30例肝炎后肝硬化患者进行事件相关电位P_(300)和脑诱发电位检查及MMSE检测,并观察1 a后临床肝性脑病(HE)的出现情况.结果:事件相关电位P_(300)异常21例(70.0%),体感诱发电位(SEP)异常11例(36.7%),MMSE得分<27(提示有认知功能障碍)13例(43.3%),事件相关电位P_(300)和/或MMSE异常22例(73.3%),两者均异常10例(33.3%),追踪观察1 a的23位患者中,17例事件相关电位P_(300)和/或MMSE异常患者出现临床肝性脑病12例,两者均无异常的6例患者中,出现临床肝性脑病1例,两者比较有显著性差异(70.6% vs 16.7%,P<0.05).结论:事件相关电位P_(300)和MMSE可作为判断肝硬化失代偿期是否发生轻微型肝性脑病的一种敏感又可靠的方法.
AIM： To estimate the value of event related potential （ERP） P300 and mini-mental state examination （MMSE） in the detection of minimal hepatic encephalopathy （MHE）. METHODS： ERP P300 and somatosensory evoked potential （SEP） were examined, and MMSE were performed in 30 posthepatitic cirrhosis patients, and the occurrence of hepatic encephalopathy （HE） was observed 1 year after examination. RESULTS： Abnormal ERP P300 occurred in 21 patients （70.0%）, while abnormal SEP occurred in 11 （36.7%）. MMSE scores less than 27 were found in 13 （43.3%） cases, and both or either abnormity of ERP P300 and MMSE were observed in 22 （73.3%）. Ten cases （33.3%） were found with abnormity of both ERP P300 and MMSE. After 1 year, of the 17 patients with abnormity of ERP P300 and/or MMSE, 12 cases developed clinical hepatic encephalopathy, while of the 6 patients without abnormal ERP P300 and MMSE, only 1 case developed clinical hepatic encephalopathy. There was significant difference between them （70.6% vs 16.7%, P 〈 0.05）. CONCLUSION： ERP P300 and MMSE were sensitive and reliable to evaluate the occurrence of MHE in liver cirrhosis.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第14期1662-1664,共3页
World Chinese Journal of Digestology
