摘要
分别对幼年、成年及老年大鼠耳蜗核的体积、神经元的核仁体积和耳蜗核神经元的数量进行检测。结果示：老年大鼠耳蜗核体积与成年组相差无显著性意义（P＞0．05）；神经元核仁体积，老年组较其它两组有极显著性缩小（P＜0．01）；老年组球形细胞和多极细胞均明显减少（P＜0．01）；梭形细胞与其它两组相差无显著意义，而胶质细胞极明显增多，平均增多48．5％（P＜0．01）。表明老年性聋的病理变化不仅发生在耳蜗，而区发生在蜗神经核。认识了这一点，对于进一步理解老年性聋的发病机理，指导临床工作具有重要意义。
The volume of cochlear nucleus and nucleolus,neural populations were determined in rats of three groups aged(1, 2-3, 22-28 months). The study data indicated that there is no dif ference between the volume of cochlear nucleus in the aged and adult animals (P>0.05). Com pared with the other two groups, the aged animals show a reduction of volume of necleolus of cochlear nucleus neurons (P<0.01), a loss of neurons (spherical cell and multipolar cell) (P< 0. 01). On the other hand, it shows an increase in number for the glial cells in the aged animals (48. 48%, P<0. 01). Quantitative results of the cell of cochlear nucleus were analysed. We sug gest that central changes also play an important role in presbycusis.
出处
《临床耳鼻咽喉科杂志》
CSCD
1997年第3期99-102,共4页
Journal of Clinical Otorhinolaryngology
基金
国家自然科学基金
