摘要
目的 分析非小细胞肺癌（NSCLC）中信号转导蛋白AKT的活化状态磷酸化AKT（P—AKT）的表达及意义。方法 应用免疫组织化学的方法，检测80例NSCLC组织及35例良性肺病变组织标本中P—AKT的表达，并与临床病理因素进行相关性分析。结果 P—AKT在NSCLC中高表达，阳性率为78．8％，而在良性肺病变组织中不表达（P〈0．05），P—AKT在不同年龄、性别、TNM分期、组织分化以及淋巴结转移与无淋巴结转移组均高表达，组间对比差异无统计学意义（P〉0．05）。结论 在NSCLC中存在AKT的活化，P—AKT参与肺癌的发生和发展。AKT的活化在NSCLC中不仅是一个频发事件，而且是一个普遍事件。针对AKT的靶位点治疗有可能对各期、各型NSCLC产生治疗作用。
Objective To investigate the expression and clinical significance of signalling protein phospho - AKT in human non - small cell lung cancer （NSCLC） tissue. Methods The expression of p - AKT in 80 cases of NSCLC and 35 cases of no - cancerous lung disease were assessed by immunohistochemistry, and its correlations with clinicopathologic factors were statistically analyzed. Results The positive rate of p - AKT was 78, 8% in NSCLC and 0 （ P 〈 0. 05 ） in no - cancerous lung disease, The positive rate of p - AKT were present with a similar high frequency in different years group, male and female, different histologic type, tumor differentiation, TNM stages, the group with and without lymph node metastasis, the difference between matchable groups was not significant （ P 〈 0.05 ）. Conclusion AKT activation may be present in NSCLC. p - AKT may frequently and popularly participate in lung carcinogenesis and development of NSCLC.
出处
《中原医刊》
2007年第15期10-11,共2页
Central Plains Medical Journal
