摘要
脑缺血损伤模型多采用全脑缺血或开颅结扎大脑中动脉等,两者或与临床患者发病过程相差甚远;或因手术创伤较大均未能广泛推广。我们改进了大鼠局灶性脑缺血模型,按Zea Longa的评分标准,全部为成功模型。模型组动物的脑梗塞体积、脑水肿、乳酸和SOD和MDA的变化,均与对照组有显著差异。模型有以下优点:解剖特点与人脑接近;手术创口小,定位准确,脑组织暴露外界时间短;梗塞部位与范围较恒定,重复性较好;术后病死率低,存活时间长。
Under surgical microscope, the starting point of left middle cerebral artery (LMCA) was blocked with electronic solidify so that the blood flow in this areas will be stoped-a new method of the middle cerebral artery occlusion. About after 24 hours, these rats will have been measured include animal's behave and the content of water in brain, the mase of necrosis of cere-bral tissue, SOD level and MDA content. It suggested that the model have some advantages than the other model, which may accuratly location, and less damage, good repeative and so on.
出处
《河北医药》
CAS
1997年第3期131-132,共2页
Hebei Medical Journal
关键词
脑缺血
动物模型
大鼠
Cerebral ischemia Animal model Rat
