摘要
背景:功能性消化不良(FD)的发病机制还不十分清楚,目前尚缺乏令人满意的治疗方法。目的:评价荆花胃康胶丸对FD的治疗效果。方法:采用开放、随机、对照试验,60例FD患者随机分为两组,每组30例,分别予口服荆花胃康胶丸160mg,3次/d和多潘立酮10mg,3次/d。根据治疗前后胃排空试验结果和消化不良症状(上腹不适、餐后饱胀、早饱、上腹痛、烧心、反酸、嗳气、食欲不振)积分的比较,评估荆花胃康胶丸的疗效和安全性。结果:治疗后两组患者餐后2h胃排空率均有所提高,治疗前后胃排空率差异有统计学意义(荆花胃康胶丸组,P<0.05;多潘立酮组,P<0.01)。两组比较,多潘立酮组治疗后胃排空率较荆花胃康胶丸组显著提高,差异有统计学意义(P<0.05)。治疗后两组患者的症状总积分均较治疗前显著下降(P<0.01)。通过两组差值的比较,荆花胃康胶丸组餐后饱胀、上腹痛、嗳气的改善程度尤其优于多潘立酮组(P<0.01)。结论:荆花胃康胶丸治疗FD具有一定的疗效,在改善消化不良症状方面优于多潘立酮,并具有良好的安全性。
Background： The pathogenesis of functional dyspepsia （FD） is not clearly known and there is no satisfactory treatment yet. Aims： To evaluate the efficacy of Jinghua Weikang Capsule （JWC） on FD. Methods： An open, randomized, controlled clinical study was carried out. Sixty patients with FD were randomly divided into two groups with 30 patients each. JWC 160 mg 3 times per day and domperidone 10 mg 3 times per day were given orally, respectively. The therapeutic efficacies of JWC and domperidone were evaluated by improvement in gastric emptying time and the improvement in the total score of dyspeptic symptoms （upper abdominal discomfort, flatulence after meal, early satiety, upper abdominal pain, heartburn, acid reflux, belching and loss of appetite）. Results： Both groups showed significant improvement of gastric emptying time after treatment （JWC group, P〈0.05; domperidone group, P〈0.01）, the efficacy was more conspicuous in domperidone group than that in JWC group （P〈0.05）. The total score of dyspeptic symptoms improved significantly after treatment in both groups （P〈0.01） and the improvement of dyspeptic symptoms such as flatulence after meal, upper abdominal pain and belching was more remarkable in JWC group than those in domperidone group （P〈0.01）. Conclusions： JWC has definite effects and is safe for FD, its effect on improvement of dyspeptic symptoms is more obvious than domperidone.
出处
《胃肠病学》
2007年第7期408-410,共3页
Chinese Journal of Gastroenterology
