摘要
目的：探讨肝硬变门脉高压性胃粘膜损害出血的机制．方法：应用放射自显影技术观察肝硬变门脉高压（ＬＣ－ＰＨＴ）大鼠在饥饿１２～３６ｈ后的胃粘膜上皮细胞标记指数（ＬＩ）变化及其与胃粘膜出血的关系．结果：①ＬＣ－ＰＨＴ鼠平均ＬＩ低于对照（Ｐ＜０．０５）．出血灶局部ＬＩ低于周围相对正常粘膜（Ｐ＜０．０５）．②随饥饿持续时间延长ＬＩ呈降低趋势，而出血率及严重程度呈增加趋势，尤以严重程度增加为著．③当出血为０～３级时与ＬＩ呈显著负相关（ｒ＝－０．７０８，Ｐ＜０．０１）；为３～４级时两者间呈正相关但未达显著水平（Ｐ＞０．０５）．结论：大鼠胃粘膜损害及出血的发生与粘膜上皮细胞增殖活性有关，ＬＣ－ＰＨＴ鼠粘膜上皮细胞增殖活性明显降低，可能是其易发严重损害及出血的重要原因．
Objective: In order to discover the mechanism of gastric mucosal hemorrhage in portal hypertension. Methods: The techniques of autoradiography were employed to research the cytokinetics of gastric mucosa in rats with liver cirrhosis and portal hypertension (LC PHT) 12～36 h after starvation. Results: (1) 3H TdR labelling index (LI) of gastric mucosa in LC PHT rats was lower than that in controls ( P <0.05). LI in hemorrhagic position was also lower than that in near position ( P <0.05). (2) With the extension of starved duration time, the rate and severity of hemorrhagic lesions in LC PHT rats was increased more than that in controls and LI in LC PHT rats was decreased more than that in controls ( P <0.01). (3) There was a relationship between LI and severity of hemorrhagic lesions. LI correlated negatively with the severity from 0～3 degree ( r =-0.708, P <0.01), and LI correlated positively with the severity from 3～4 degree ( r = 0.41 , P >0.05). Conclusion: The results suggest that the lower level of gastric mucosa LI in LC PHT rats might render the gastric mucosa more susceptible to injurious agents and hemorrhagia.
出处
《第四军医大学学报》
1997年第3期266-269,共4页
Journal of the Fourth Military Medical University
关键词
胃粘膜损害
出血
细胞动力学
门脉高血压性
liver cirrhosis portal hypertension gastric mucosa hemorrhagic lesions autoradiography rats
