摘要
现已证实,环氧化酶2（COX-2）不仅参与炎症反应,在各种恶性肿瘤亦有不同程度的表达。目前许多临床前期实验皆证实COX-2通过多种致癌机制在肺肿瘤的发生、发展、转移和预后扮演很重要的角色。因此,COX-2抑制剂为当前研究治疗肺癌的新靶点之一。现国外学者已针对COX-2抑制剂在肺癌治疗的应用进行临床实验。本文就COX-2与肺癌的关系和COX-2抑制剂在肺癌临床应用中的研究进展综述如下。
It has already proved cyclooxygenase 2 （COX-2） not only participates in inflammatory reaction, but also expresses in different malignancies in different degrees. Several preclinical experiments have proved COX-2 plays an important role in the pathogenesis, progress, metastasis and prognosis of lung cancer through different （carcinogenic） mechanisms. It has been a new research subject in the treatment of lung cancer. Clinical experiments are carried out in foreign countries concerning the use of COX-2 inhibitors in lung cancer. This article summaries the research advances on the relation of COX-2 and lung cancer and the clinical application of COX-2 inhibitors in the treatment of lung cancer as follows.
出处
《国际呼吸杂志》
2007年第16期1268-1271,共4页
International Journal of Respiration
关键词
环氧化酶-2抑制剂
肺癌
治疗
Cyclooxygenase-2 inhibitor
Lung cancer
Treatment
