摘要
目的:研究原发性高血压患者血内皮素浓度的变化,探讨高血压与内皮素升高的关系。方法:用放射免疫法测定40例原发性高血压血内皮素含量,并与40例健康人(对照组)进行对照分析。结果:高血压组内皮素升高,与对照组比较差异具有非常显著性意义(P<0.001),并与血压升高程度呈正相关,高血压组Ⅱ、Ⅲ级与Ⅰ级比较差异具有非常显著性的意义(P<0.01),Ⅲ级与Ⅱ级比较差异具有非常显著性的意义(P<0.01)。原发性高血压并发左心室肥厚(LVH)、心力衰竭组与单纯高血压组内皮素含量比较具有非常显著性的意义(P<0.01,P<0.001);并发心力衰竭组与并发LVH组内皮素含量比较差异具有非常显著性的意义(P<0.01)。结论:内皮素是高血压病理发展过程中的重要参与因素,可作为反映高血压病变程度和动态变化的一项指标,有一定的参考价值。
Objective：To study the variation of blood endothelin concentration among essential hypertension patients and discuss the relation- ship between hypertension and the rise in endothelin level. Methods：The blood endothelin level of 40 cases of hypertension patients with ridio immuno assay was measured and comparison analysis against 40 cases of healthy people was conducted. Results： Hypertension patients had higher level of endothelin,with direct proportion to the degree of rise in blood pressure（ P 〈 0. 001 ）. There was an obvious difference between Group 11 ,Ⅲ and I （P 〈 0.01 ） and between Group llI and II （ P 〈 0.01 ） but higher in the case of supervening left ventricular hypertrophy or heart failure （ P 〈 0.01 ,P 〈 0. 001 ）. When compared with the control group the difference was significant betwwen the endothelin level of the heart failure group and the LVH group（P 〈0.01 ）. Conclusion：Endothelin is an important influencing factor of hypertension physiologic and pathologic change process. It can be an indicator of reflecting hypertension pathological process degree and dynamic changes and therefore is a valuable reference.
出处
《华北国防医药》
2007年第4期9-10,共2页
Medical Journal of Beijing Military Region
关键词
高血压
原发性
内皮素
左心室肥厚
心力衰竭
充血性
Hypertension, primary
Endothelin
Left ventricalar hypertrophy
Heart failure, congestion
