期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

vWF、Ps水平与冠心病中医证型相关性的临床研究 被引量：7

The Clinical Research on the Relation of vWF, Ps level and TCM Syndromes of Coronary Heart Disease
在线阅读 下载PDF
导出
摘要 目的:探讨血管内皮功能指标血管性血友病因子(vWF)、P-选择素(Ps)水平与冠心病中医证型的关系。方法:174例冠心病辨证分为心血瘀阻证、痰阻心脉证、阴寒凝滞证、心肾阴虚证、气阴两虚证、阳气虚衰证6组。同时应用酶联免疫吸附法(ELISA)、流式细胞术检测法分别测定冠心病组和31名健康者对照组血浆vWF、Ps的水平,并对不同证型的指标进行比较。结果:心血瘀阻、痰阻心脉、心肾阴虚、气阴两虚四型血浆vWF、Ps水平较对照组明显升高(P<0.05);心血瘀阻、痰阻心脉二型血浆vWF、Ps水平均高于心肾阴虚、气阴两虚二型(P<0.05),心血瘀阻与痰阻心脉、心肾阴虚与气阴两虚型之间比较无显著性差异(P>0.05)。结论:血浆vWF、Ps水平与冠心病中医辨证分型存在一定相关性。
作者 陈昕琳 顼志兵 顾仁樾
机构地区 上海中医药大学附属龙华医院
出处 《湖北中医杂志》 2007年第8期11-12,共2页 Hubei Journal of Traditional Chinese Medicine
关键词 冠心病 胸痹心痛 血管性血友病因子 P-选择素 证候研究
分类号 R256.22 [医药卫生—中医内科学]
  • 相关文献

参考文献12

  • 1Lip GYH,Blann A.von Willebrand fhctor:a marker of endothelial dysfunction in vascular disorders[J].Cardiovase Res,1997,34(2):255-265.
  • 2JMorange Pe,Simon C,Alessi MC,et al.Endothelial cell markers and the risk of coronary heart disease:the Prospective Epidemiological Study of Myocardial Infarction(PRIME)study[J].Circulation,2004,109(11):1343-1348.
  • 3Blann AD,Dobrotova M,Kubisz P,et al.Von willebrand factor,soluble P-selectin,tissue plasminogen activator and plasminogen activator inhibitor in atherosclerosis[J].Thromb Haemost,1995,74:626-630.
  • 4国际心脏病学协会,世界卫生组织临床命名标准化专题组.缺血性心脏病的命名和诊断标准[S].1979.
  • 5中华人民共和国卫生部.中药新药临床研究指导原则[S].,2002..
  • 6Briede JJ,Wielders SJ,Heemskerk JW,et al.von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets[J].J Thromb Haemost,2003,1(3):559-565.
  • 7Vanhoorelbeke K,Ulrichts H,Schoohneester A,et al.Inhibition of platelet adhesion to collagen as a new target for antithrombotic drugs[J].Curr Drug Targets Cardiovase Haematol Disrod,2003,3(2):125-140.
  • 8谭文锋.冠心病患者血小板活化状态的探讨[J].临床医学,2000,20(12):1-2. 被引量：6
  • 9McEver RP,Beckstead JH,Moore KL.Et al.GMP-140,a platelet a-lpha-granule membrane protein is also synthesized by vascular endothelial cells and is localized in weibel-paladed bodies[J].J Clin Invest,1989,84:92-99.
  • 10KaiKita K,Ogawa H,Yasure H,et al.Soluble P-selectin is released into the coronary circulation after coronary spasm[J].Circulation,1995,92,1726-1730.

二级参考文献13

  • 1张琳,崔让庄,毛用敏,朱天慧.人血DNA的提取方法[J].天津医药,1993,21(2):112-114. 被引量：5
  • 2黄惠勇.冠心病“本虚标虚”病机内涵探析[J].北京中医药大学学报,1994,17(2):10-11. 被引量：18
  • 3Harvey PJ, Keightley AM, Lam YM, et al. A single nucleotide polymorphism at nucleotide - 1793 in the yon willebrand factor regulartory region is associated with plasma vwf :Ag level. Br J Haematol, 2000, 109(2): 349-353.
  • 4Lip GY, Blann AD. von Willebrand factor : a marker of endothelial dysfunction in vascular disorder? Cardiovasc Res 1997,34(2) : 255-265.
  • 5Lip GY, Blann AD. von Willebrand factor and its relevance to cardiovascular disorder. Br Heart J, 1995,74(6) : 580 - 583.
  • 6Kumari M, Marmot M, Brunner E, et al. Social determinants of von willebrand factor: the white study. Arterioscler Thromb Vasc Biol, 2000, 20(7) : 1842-1847.
  • 7Wiman B, Andersson T, Hallqvist J, et al. Plasma level of tissue plasminogen activator/ plasminogen activator inhibitor- 1 complex and von willebrand factor are significant risk markers for recurrent myocardial infarctionin the Stockholm Heart Epidemiology Program(SHEEP) study. Arteriolscler Thromb Vasc Biol, 2000, 20(8) : 2019 - 2023.
  • 8Whincup PH, Danesh MM, Walker, et al. von Willebrand factor and coronary heart disease, prospective study snd meta - analysis. Euro Heart J, 2002, (23):1764-1770.
  • 9Lacquemant C, Gaucher C, Delorme C, et al. Association between high yon willebrand factor level and the Thr789Ala vwf gene polymorphism but not with nephropathy in type I diabetes. The GENEDIAB study group and the DESIR study group. Kidney Int, 2000, 57(4) : 1437 - 1443.
  • 10Jorieux S, Fressinaud E, Goudemand J, et al. Confirmational changes in the D/ domain of yon willebrand factor induced by CYS25 and CYS95 mutations lead to factor VII binding defect and muhimeric impairment. Blood, 1995(10) : 3139-3145.

共引文献63

同被引文献206

引证文献7

二级引证文献69

湖北中医杂志
2007年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部