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阻塞性睡眠呼吸暂停低通气综合征血浆尾加压素Ⅱ检测及其意义

Urotensin Ⅱ levels of the plasma in obstructive sleep apnea syndrome patients and the pathological significance.
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摘要 目的探讨不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆尾加压素Ⅱ(UⅡ)水平的变化,分析其在OSAHS发生发展中的作用。方法将2005年4月至2005年12月于温州医学院附属第一人民医院睡眠中心行多导睡眠(PSG)监测的鼾症患者60例分为单纯鼾症组和轻、中、重度OSAHS组,每组各15例。选取15名健康体检者为正常对照组。检测各组UⅡ水平,进行相关性分析。结果UⅡ水平正常对照组(1.14±0.65)ng/L、单纯鼾症组(1.37±0.42)ng/L、轻度OSAHS组(10.44±4.12)ng/L、中度OSAHS组(38.55±15.8)ng/L、重度OSAHS组(94.78±19.63)ng/L,单纯鼾症组与轻、中、重度OSAHS组两两比较,组间差异均有显著性意义(P<0.01)。结论UⅡ可能是参与OSAHS发生、发展的重要因素。 Objective To study the levels of Urotensin Ⅱ ( U Ⅱ ) in the different grades of obstructive sleep apnea syndrome(OSAHS) patients and the correlation of U Ⅱ to OSAHS. Methods Seventy-five OSAHS patients were divided into five groups according to light, medium,serious AHI ,simple snorers and normal part;U Ⅱ levels of the plasma were measured and correlation analysed. Results U Ⅱ levels :light group( 10.44 ± 4. 12 ) ng/L, medium group ( 38.55 ± 15.8 ) ng/ L,serious group(94. 78 ± 19. 63 ) ng/L ,simple snorers group( 1.37 ± 0. 42 ) ng/L,normal group( 1.14 ± 0.65 ) ng/L. Statistic difference existed among these groups( P 〈0. 01 ). Conclusion U Ⅱ may be a kind of significant cause in the development of OSAHS.
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2007年第5期356-357,共2页 Chinese Journal of Practical Internal Medicine
关键词 睡眠呼吸暂停 阻塞性 尾加压素Ⅱ Sleep apnea,obstructive Urotensin Ⅱ
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