抗精神病药物与脂肪肝的相关性研究被引量：13

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摘要目的:探讨抗精神病药物与脂肪肝的相关性。方法:利用B超观察268例长期单一使用抗精神病药物的精神分裂症患者的肝脏情况,并检测其血脂及肝功能指标。结果:抗精神病药物致脂肪肝的患病率为42.5%;脂肪肝的患病率与用药年限呈显著相关(p<0.05);脂肪肝患者甘油三酯(TG),谷丙转氨酶(ALT)显著增高。结论:长期服用抗精神病药物治疗精神分裂症,患者的脂肪肝发生率较高,定期进行肝脏超声检查、血脂、肝功能检测对指导临床早期发现脂肪肝及合理用药有重要意义。

作者王培芳

机构地区湖北省孝感市康复医院

出处《中国药物滥用防治杂志》 CAS 2007年第4期245-246,共2页 Chinese Journal of Drug Abuse Prevention and Treatment

关键词抗精神病药物脂肪肝精神分裂症肝功能

分类号 R595.3 [医药卫生—内科学]

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参考文献2

1王从杰,张志珺,孙静,张晓斌,牟晓冬,张向荣,尚晓芳,张太泉.长期使用抗精神病药患者血清游离脂肪酸水平与有关因素研究[J].临床精神医学杂志,2005,15(5):257-259. 被引量：3
2范建高.代谢综合征与脂肪肝[J].国外医学（内分泌学分册）,2002,22(5):273-275. 被引量：133

二级参考文献10

1孙静,张志珺,王丛杰,张晓斌,王筱兰,尚晓芳,朱荣鑫.长期服用抗精神病药对脂肪酸与血糖的影响[J].临床精神医学杂志,2004,14(5):259-261. 被引量：12
2王从杰,孙静,张志珺.抗精神病药与2型糖尿病[J].临床精神医学杂志,2004,14(5):313-314. 被引量：18
3Lieberman JA,Tollefson G,Tohen M,et al.Comparative efficacy and safety of atyipical and conventional antipsychotic drugs in first-episode psychosis:A randomized,double-blind trial of olanzapine versus haloperidol[J].Am J Psychiatry,2003,160:1401-1403.
4Carpentier A,Mittelman SD,Lamrche B,et al.Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation[J].Am J Physiol,1999,276:1055-1066.
5Buse JB.Metabolic side effects of antipsychotics:focus on hyperglycemia and diabetes[J].J Clin Psychiatry,2002,63:3.
6Newcomer JW.Metabolic disturbances associated with antipsychotic use[J].J Clin Psychiatry,2001,62:3.
7Hawkins M,Tonelli J,Kishore P.Contribution of elevated free acid levels to the lack of glucose effectives in type 2 diabetes[J].Diabetes,2003,52:2748.
8Tremblay F,Lavigne C,Jacques H,et al.Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alternation in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities[J].Diabetes,2001,50:1901-1910.
9Chu CA,Sherck SM,Igawa K.Effects of free fatty acids on heptic glycogenolysis and gluconeo-genesis in conscious dogs[J].Am J Psychol,Endocrinal Metab, 2002,282:402-411.
10Lupi R,Dtta F,Marselli L,et al.Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets[J].Diabetes,2002,51:1437-1442.