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丝裂原活化蛋白激酶在疼痛信号调制中的作用 被引量：3

Role of MAP kinase cascades in pain modulation
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摘要 丝裂原活化蛋白激酶(MAPK)是哺乳动物体内参与胞内信号传导的重要激酶。主要有3条激活途径:ERK/MAPK、JNK/SAPK和P38MAPK。研究表明,这3条信号通路在疼痛,尤其是病理性疼痛的产生和维持中发挥重要作用。本文综述这方面的研究进展,进一步阐明了其详细的作用机制,很可能为疼痛性疾病的治疗提供一个良好的前景。 Mitogen-activated protein kinases （MAPKs） are important kinases involved in the intraceUular signaling transduction in mammalian. There are three major MAPK pathways： ERK/MAPK, JNK/SAPK and P38 MAPK. Current studies indicate that all of them play significant roles in the processing of pain especially in the development and maintenance of pathological pain. This review will focus on in the study of MAPK in pain modulation. The further insights into its mechanisms may highlight a nice prospect for the therapies of painful diseases.
作者 陆颖 朱俐 高永静
机构地区 南通大学航海医学研究所
出处 《基础医学与临床》 CSCD 北大核心 2007年第8期948-952,共5页 Basic and Clinical Medicine
基金 国家自然科学基金(30500153) 江苏省高校自然科学研究计划(05KJB180100)
关键词 丝裂原活化蛋白激酶 疼痛 中枢敏化 神经元可塑性 mitogen-activated protein kinases pain central sensitization neuronal plasticity
分类号 R402 [医药卫生—临床医学]
  • 相关文献

参考文献22

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二级参考文献10

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共引文献6

同被引文献54

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引证文献3

二级引证文献10

基础医学与临床
2007年 第8期

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