摘要
目的:探讨老年人急性药物性肝病的常见诱发药物、临床表现、分型及预防,以提高对该病的诊断水平.方法:对符合诊断标准的30例急性药物性肝病患者的临床资料进行回顾性分析.结果:诱发老年人急性药物性肝病的药物中,中草药9例(30.3%),抗生素5例(16.7%),解热镇痛药,碘油造影剂和抗甲亢药均3例(10.0%),其他7例(23.3%).临床表现为急性肝细胞型20例(66.7%),急性胆汁淤积型3例(10%),混合型7例(23.3%).其中治愈18例(60.0%),好转8例(26.7%),恶化2例(6.7%),死亡2例(6.7%).结论:老年人对药物敏感性增加,容易引起急性药物性肝损伤和不良反应,临床医生必须加以高度重视,谨慎用药.
AIM： To review common inducing drugs and their clinical manifestations, to discuss the grouping and prognosis of acute drug induced liver disease （ADLD） in the elderly, and to enhance the diagnosis capabilities and management of ADLD.
METHODS： A retrospective-study to 30 cases of ADLD, chosen according to diagnosis standards.
RESULTS： The types of drugs inducing ADLD were as follows： 9 cases of traditional and herbal drugs （30.3%）; 5 of antibiotics （16.7%）; 3 each of nonsteroidal anti-inflammatory, iodized oil roentgenograph, and anti-hyperthyroidism drugs （30.0%）; and 7 others （23.3%）. Manifestations were： acute hepatocellular lesions, 20 cases （66.7%）; acute cholestasis, 3 cases （10.0%）; mixed type, 7 cases （23.3%）. Curative effects were： 18 cases of a cure （60.0%）, 8 improvements （26.7%）, 2 deteriorations （6.7%）, and 2 deaths （6.7%）.
CONCLUSION： The elderly are more sensitive and have less reserved organ functions than younger age groups. Thus it is easier for acute drug induced liver disease to occur in the el- derly, especially in patients with other chronic diseases. As side-effects can be very serious, cli- nicians need to pay attention to ADLD and exercise great care regarding drug use in the elderly.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第18期2059-2062,共4页
World Chinese Journal of Digestology
关键词
老年
急性药物性肝病
不良反应
Elderly
Acute drug inducing liver diseases
Side-effect
