摘要
骨髓增生异常综合征(MDS)以难治性全血细胞减少和易转化为急性白血病为特征。患者的预后、合并症和年龄是决定治疗策略时必须考虑的因素。治疗策略经常以支持治疗为主,包括造血细胞生成因子、输注红细胞和血小板以及抗感染治疗。另外诱导分化、免疫抑制治疗、刺激造血、靶向治疗、化疗、异基因骨髓移植等根据具体病情选择应用。我们明确提出“气阴两虚,血瘀内阻”的中医复合证候为MDS临床主证,以“益气养阴活血”为治疗大法,制成“益髓颗粒剂”,进行了大量实验及临床研究,获得了确切疗效。
Myelodysplastic syndromes （MDS） are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis resulting in peripheral cytopenia leading to transfusion-dependent anemia, an increased risk of infection or bleeding, and a propensity for development of acute myeloid leukemia （AML）. The prognosis, co-morbidities and age of a patient must all be considered when deciding treatment strategies. The advanced age of the majority of MDS patients limits the therapeutic strategies often to supportive care measures, including hematopoietic growth factors, red blood cell or platelet transfusions, and antimicrobial agents.To address these shortcomings, much effort has been directed toward the development of novel treatment strategies that target the evolution and proliferation of malignant clones.In the theory of traditional chinese medicine ,there are mainly 3 pathogens to ITP： deficiency of qi and yin and blood stasis. According to the pathogens , the treatment is to supplement qi and yin, activate blood and stanch bleeding. The Chinese herb Yi Sui granule can make it.
关键词
骨髓增生异常综合征
益气养阴活血法
益髓颗粒剂
Myelodysplastic syndromes （MDS）
Supplementing qi and yin, activating blood
Yi Sui granule
