摘要
As an important subset of regulatory T （Treg） cells, IL-10-producing type 1 regulatory T cells （Trl）, have some different features to thymic-derived naturally occurring CD4^＋CD25^＋Foxp3^＋ Treg cells（nTreg cells）. Similar to nTreg cells, Trl also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Trl and Th2 responses in healthy subjects. Skewing of allergic-specific effctor T cells to a Trl phenotype appears to be a critical event in successful allergen-specific immunotherapy and glucocorticoids and β2-agonists treatment. Trl suppress Th2 cells and effector cells of allergic inflammation, such as eosinophils, mast cells, basophils, through producing IL-10, and perhaps TGF-β. Understanding of Trl may be helpful in developing new strategies for treatment of allergic diseases.
As an important subset of regulatory T （Treg） cells, IL-10-producing type 1 regulatory T cells （Trl）, have some different features to thymic-derived naturally occurring CD4^＋CD25^＋Foxp3^＋ Treg cells（nTreg cells）. Similar to nTreg cells, Trl also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Trl and Th2 responses in healthy subjects. Skewing of allergic-specific effctor T cells to a Trl phenotype appears to be a critical event in successful allergen-specific immunotherapy and glucocorticoids and β2-agonists treatment. Trl suppress Th2 cells and effector cells of allergic inflammation, such as eosinophils, mast cells, basophils, through producing IL-10, and perhaps TGF-β. Understanding of Trl may be helpful in developing new strategies for treatment of allergic diseases.
