摘要
甲脒类农药双甲脒对大鼠不同脑区α2-肾上腺素受体的作用及其蓄积效应研究结果表明,一次大剂量双甲脒(70mg/kg)明显抑制大脑皮层和脑干的3H-可乐定结合,但对海马、纹状体和小脑的3H-可乐定结合无影响。这一毒作用特征与α2-肾上腺素受体的脑区分布相一致。低剂量双甲脒染毒对α2-肾上腺素受体的蓄积作用不大。
This paper presented the effects of amitraz(a formamidine pesticide )on α 2 adrenoceptors in different brain areas of rats. The results showed that a single dose of amitraz(70mg/kg,i.p.)significantly decreased