摘要
目的评价早期帕金森病(PD)患者睡眠质量,探讨早期PD患者睡眠结构异常表现及睡眠障碍相关因素。方法选取PD患者53例,以匹兹堡睡眠质量指数(PSQI)量表评定PD患者最近1个月的睡眠质量,并进行Hamilton抑郁量表评分,UPDRSⅢ、Hoehn-Yahr分期、Schwab和England量表评分和改良Weber评分。结果早期PD患者睡眠障碍的发生率为66%(35/53)。Hamilton抑郁评分、年龄与患者睡眠障碍相关r分别为0.511(P=0.000)和0.299(P=0.012)。睡眠障碍组和无睡眠障碍组主观睡眠质量(F1)、入睡时间(F2)、睡眠时间(F3)、睡眠效率(F4)、睡眠干扰(F5)存在差异。不同药物治疗组间睡眠障碍的发生率无差异。结论早期PD患者存在睡眠障碍,且和Hamilton抑郁评分、年龄相关。需关注早期PD患者睡眠质量,提高整体治疗效果。
Objective To evaluate the quality of sleep and investigate the abnormal appearance of sleep structure and factors associated with sleep disorder in patients with early Parkinson＇s disease （PD）. Methods Fifty-three early PD patients were enrolled in this study. Pittsburgh Sleep Quality Index was used to evaluate sleep quality in a recent month,as well as the Hamiltion Depression Scale, Unified Parkinson＇s Disease Rating Scale（UPDRS） Ⅲ, Hoehn-Yahr Scale, the Schwab and England disability scale and improved Weber Scale were performed. Results The incidence of sleep disorders in patients with early PD was 66 % （35/53）. The score of Hamilton Depression Scale and age were closely correlated with patients＇ sleep disorders（r=0. 511 ,P=0. 000; r=0. 299, P=0. 012）. There were no marked differences in subjective sleep （ F1 ）, quality sleep latency （F2）, sleep duration hatitual （F3）, sleep efficiency（F4） and sleep disturbances（F5） between sleep disorder group and non-sleep disorder group. The incidence rate of sleep disorder was not significantly different among the groups treated with different kinds of drugs. Conclusion Sleep disorders exist in patients with early PD and were associated with the score of Hamilton Depression Scale and age. Sleep quality should be paid attention to in patients with early PD for improving the effects of treatments.
出处
《江苏医药》
CAS
CSCD
北大核心
2007年第9期897-899,共3页
Jiangsu Medical Journal
关键词
帕金森病
睡眠障碍
Parkinson＇s disease
Sleep disorder
