摘要
目的了解我国肝脏肿瘤的发生特点及其临床病理特征。方法用常规病理方法分析了手术切除的３１６０例肝脏肿瘤的构成及临床病理特点，共涉及三个胚层来源的２５类肿瘤。结果肝脏瘤样病变４种，１１２例，占３．５％，肝脏良性肿瘤１０种，４９９例，占１５．８％，肝脏恶性肿瘤１１种，２５４９例，占８０．７％。三组中最为常见的分别是炎性假瘤（占该组的７３．２％），肝海绵状血管瘤（占该组的７４．３％）和肝细胞癌（占该组的９６．８％）。三组患者在年龄与性别比上有所不同。肝细胞癌的血清ＨＢｓＡｇ阳性率和肝硬化伴发率分别为７４．４％和７２．０％，＜３ｃｍ小肝癌的肝硬化合并率高达８３．２％。结论结果表明，ＨＢＶ感染和肝硬化与肝细胞癌的发生有密切关系。
Objective\ To study the developmental and clinicopathological characteristics of liver tumors in China.Methods\ Routine methods were utilized to analyse the composition and clinicopathological features of 3 160 cases of liver tumors which were surgically resected during a period of 14 years. Results\ 25 types of liver tumors arising from three germinal layers were studied.Tumor like lesions,4 types,112 cases(3.5%);benign tumors,10 types,499 cases(15.8%);malignant tumors,11types, 2 549 cases(80.7%).Of its invasion and metastasis.Methods\ 34 cases of HCC and their pericarcinomatous tissues were studied on cryostat sections by in situ hybridization to investigate ICAM 1mRNA expression.Results\ The ICAM 1 mRNA expression was stronger in the carcinomatous tissues of 19/21invasive cases than that in the pericarcinomatous tis sues,while in the13non invasive cases,only4exhibited weak ICAM 1mRNA expression.Conclusion\ ICAM 1mRNA expression may correlate with increased risk of invasion and metastasis of HCC.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1997年第2期70-73,共4页
Chinese Journal of Pathology
关键词
肝肿瘤
肝硬化
乙型肝炎
病理
Liver neoplasms\ \ Intercellular adhesion molecule 1\ \ Neoplasm metastasis\ In situ hybridization
