摘要
学术背景:中医药在防治骨质疏松症方面具有独特优势,但目前关于该病的中药复方用药规律的研究较少,而且多以统计用药频率为主。此法往往需要大样本且须具有典型的概率分布。此外,在中医诊治过程中,个人经验也造成处方配伍用药的偏倚,药物剂量相距甚远,这使药物治疗的安全性和有效性难以保证。目的:应用灰关联分析及信息处理方法探讨治疗骨质疏松症的用药规律。检索策略:由第一、三、四作者应用计算机检索中国知网1995-01/2005-12期间的相关文献。所用中文检索词包括"骨质疏松,骨萎,中药,治疗"。共检索到169篇文献。纳入标准:①治疗方法为单纯使用中药治疗,不包括其他辅助治疗,如西药、手法、针灸等。②所有中药复方必须药味完整,剂量准确,主治明确,疗效确切。排除标准:排除含有辅助治疗及疗效不确切,药味不全、没有给出药物剂量或剂量不准确的文献。结果选出104篇符合标准的文章。文献评价:文献的来源主要是通过对治疗骨质疏松症的中药复方的相关文章进行循证医学系统查询,通过灰关联分析及信息处理方法分析查询结果,以此探讨治疗骨质疏松症的中药复方用药规律。资料综合:在治疗骨质疏松症的104首中药复方中共使用106种药物1204频次。其中,使用频次在10次以上的依次为熟地、淫洋藿、杜仲等34味中药,使用总频次为890次,灰关联系数大小依次为山药、淫羊藿、骨碎补等。性温、平,味甘、苦、辛,归肾经、肝经和脾经的药物所占比例较大。在药物分类中,补益药达到23种,占总数的67.6%。其中,又以补阳药为主,其次为补气药。结论:灰关联分析及信息处理结果认为骨质疏松症的主要病理是脾肾阳虚,其次为气虚、阴虚和血虚,在用药中主要使用补益肝肾、补脾益气、滋阴活血药。
BACKGROUND： Traditional Chinese medicine has superiorities on the treatment of osteoporosis （OP）. While the study on the regularity of compound herbal formulae for OP is still inadequate, and major focus on the usage frequency of herbs, which needs numerous samples and typical distribution of probability. Furthermore, during the course of diagnosis and cure, the personal experiences usually have biases against the herbal prescription and compatibility and the dosage vades of the same herb, which will cause uncertain securities and validities while using these herbs. OBJECTIVE： Gray relational analysis （GRA） and informational management are adopted to discuss the regularity of compound herbal formulae for OP.
RETRIEVE STRATEGY： A retrieval of China National Knowledge Infrastructure （CNKI） was undertaken by the first, second and third authors to identify the relevant articles published from January 1995 to December 2005 with the Chinese key words of ＂OP, osteanabrosis, Chinese herbs, treatment＂. Totally 169 articles were retrieved. Inclusive criteria included： ①The only way of treatment for OP was to use Chinese herbs, excluding assistant ways such as wastem medicines, massages and acupunctures. ②Each compound Chinese herbal formula must include all the herbs employed for the disease, and the dosage of each herb must be accurate, The ways of treatment for OP was clear, and the curative effect was affirmed. Exclusive criteria included the treatment for OP assisted by other ways, indefinite curative effect, herbs＇ absence, affiliated with no dosage or inaccurate dosage. Finally 104 articles met with the inclusive criteria were included. LITERATURE EVALUATION： The literatures were collected by inquiring evidence-based medicine of relevant researches on the OP treatment using compound herbal formulae, the results of which were analyzed by GRA and informational management to find the regularity of compound herbal formulae for OP. DATA SYNTHESIS： There were 104 prescriptions （totaling 106 herbs and 1 204 counts of frequency） in the compound herbal formulae for OP. The herbs which were used for more than.10 times included 34 herbs, Le. Radix Rehmanniae Preparata, Herba Epimedii and Cortex Eucommiae, etc. The total frequency of using these herbs were 890 counts and the coefficients of GRA in turn were Rhizoma Dioscoreae, Herba Epimedii and Rhizoma Drynariae, etc. The herbs were neutral and warm in nature; sweet, bitter and acrid in taste; and belonged to Shenjing point, Liver meridian and Spleen meddian by more proportion. When these herbs were classified, the tonic herbs counted for 23 kinds （67.6% of the total herbs）. Among the tonic herbs, Yang tonics were employed dominantly while Yin tonics were the secondly employed.
CONCLUSION： The results of GRA and informational management show that, treatment of OP should emphasize on the herbs that can tonify liver and kidney, invigorate spleen to replenish Qi, nourish Yin and tonify blood.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第35期7065-7068,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
