摘要
目的了解重型肝炎患者血清皮质醇浓度的变化,探讨皮质醇浓度与预后的关系。方法对102例重型肝炎患者,用放射免疫法测定血清皮质醇浓度,比较重型肝炎存活者和死亡者皮质醇浓度的变化。结果血清皮质醇浓度:102例重型肝炎患者平均为(13.51±5.25)μg/dl,30例正常人平均为(28.10±10.01μg/dl),t=8.51,P<0.01,重型肝炎患者组显著低于正常人组。重型肝炎患者49例死亡,死亡者的血清皮质醇平均为(9.31±4.29)μg/dl,53例存活者血清皮质醇平均为(17.11±5.12)μg/dl,t=6.31,P<0.01,死亡者的血清皮质醇浓度显著低于正常人组。结论重型肝炎患者的皮质醇浓度降低,存在着肾上腺皮质功能低下,皮质醇浓度越低,预后越差。
Objective To probe the changing of the level of serum cortisol in severe hepatitis and to study the relationship between the level of serum cortisol and the prognosis. Methods The level of serum cortisol was detected by RIA in 102 patients of severe hepatitis and the level of serum cortisol （in surviving cases between dead cases） was compared between surviving and dead cases. Results the level of serum cortisol of the 102 patients of severe hepatitis was 13.51±5.25μg/dl,the level was significantly lower than controls （28.10±10.01μg/dl）,t=8.51 ,p〈0.01.The level of 49 dead cases （9.31±4.29μg/dl） was lower than the level of 53 surviving cases （17.11±5.12μg/dl）,t=6.31 ,P〈 0.01.Conclusions The level of serum cortisol in severe hepatitis was lower.Therefore there was a decrease in function of the cortex of adrenal gland. The lower the level of serum eortisol,the worse the prognosis.
出处
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CAS
2007年第4期302-303,共2页
Drug Evaluation
