摘要
目的:观察补肾活血中药对实验性血瘀证大鼠血管内皮细胞功能的影响。方法:采用补肾活血中药药液灌服实验性血瘀证大鼠模型,将动物随机分为对照组、模型组、大剂量和小剂量共4组,每组10只。造模成功后,给药组灌服药物40天,然后下腔静脉取血,测定各观察指标和主动脉血管壁组织学变化。结果:补肾活血中药组血脂、血流变、内皮功能、凝血纤溶各项指标及组织形态学均有明显变化,接近正常组,与模型组有显著差异。结论:补肾活血中药有降低血液黏度、调节血脂和改善血管内皮细胞功能的作用。
Objective ：To observe the effect on endothelial cell function of blood stasis rat model of the Chinese medicine of enriching kidney and promoting blood flow. Method ：40 rats were randomly divided into 4 groups including control group ,model group ,small dose and large dose group. The medicine groups（ small dose and large dose group） were given the herb mentioned above 40 days. Take postcava blood to view the blood index and microanatomy of vessel wall. Result ： The blood fat, hemorheology, endothelial cell function, blood cogulation, histomorphology of medicine groups were improved obviously. There are significant difference between medicine groups and model group. Conclusion ： The herb of enriching kidney and promoting blood flow can depress blood wiscosity, accommodate blood fat and improve endothelial cell function.
出处
《中华中医药学刊》
CAS
2007年第9期1920-1922,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
血瘀证大鼠
补肾活血中药
血管内皮细胞功能
blood stasis rat model
Chinese medicine of enriching kidney and promoting blood flow
endothelial cell function
