摘要
为探讨中药健肾方冲剂治疗绝经后骨质疏松性腰椎骨折患者的作用机理。利用X线摄片及双能X线检测,根据骨质疏松症的诊断标准,选择60例绝经后骨质疏松性腰椎骨折患者。随机分为健肾方冲剂治疗组30例及福善美对照组30例。治疗前后检测BMD、E2、IL-6、尿HOP/Cr、尿Ca/Cr等指标。结果表明,随着治疗时间的延长,E2逐渐上升,IL-6、尿HOP/Cr及Ca/cr均明显下降;两组同一时间段相比,E2及尿Ca/Cr之间有明显差异。说明健肾方冲剂具有降低骨吸收的功能,这种功能可能与其提高体内性激素水平有关,雌激素水平升高,导致分泌IL-6细胞的抑制,使IL-6分泌减少,抑制因IL-6增高而引起的骨吸收增强,并且降低尿HOP/Cr和Ca/Cr水平。
To approach mechanism of action of JIANSHENFANGCHONGJI (JSFCJ, a powder preparation for infusion used for weakness of renal function) for patients of fracture of lumbar vertebra (FLV) related to postmenopausal osteoporosis (PMO). 60 cases of these patients were randomly divided into two groups, the JSFCJ treatment group and the Fosamax control group (n=30 cases esch), detected by X-ray photographs and dual energy X-ray absorptionmetry, according to diagnostic code of osteoporosis. Some indexes were observed before, afer treatment, such as bone mineral density (BMD), estradiol (E2), interleukin-6(IL-6), HOP/Cr and Ca/Crof urine. The results showed: E2 was rised gradually, HOP/Cr and Ca/Cr of urine decreased obviously, along extension of treatment horary. There were significant difference in E2 and Ca/Cr in urine between two groups in one time. JSFCJ could restrain bone resorption, repress externalization of IL-6 and degrade level of HOP/Cr and Ca/Cr of urine.
出处
《中医正骨》
2007年第9期4-5,共2页
The Journal of Traditional Chinese Orthopedics and Traumatology
