摘要
目的观察急性冠脉综合征(ACS)患者血浆血管性血友病因子裂解酶(vWF-cp)水平变化及临床意义。方法ACS分不稳定型心绞痛(UAP)组和急性心肌梗死(AMI)组,其中UAP17例,AMI17例,分别于急性期(入院后即刻)和恢复期(4周)采血;稳定型心绞痛(SAP)组17例和健康对照组17例,入院次日空腹采血。所有入选对象均行冠状动脉造影证实。应用残余胶原结合力试验测定血浆vWF-cp活性水平。结果①UAP组[(53.17±11.72)%]和AMI组[(46.47±11.81)%]急性期血浆vWF-cp活性水平均低于SAP组[(77.00±10.42)%],(P<0.01)和正常对照组[(80.79±17.25)%],(P<0.01),而UAP组和AMI组之间比较、SAP组和正常对照组之间比较差异无统计学意义(P均>0.05)。②UAP组(53.17±11.72)%]和AMI组[(46.47±11.81)%]vWF-cp活性水平急性期低于恢复期[UAP组(79.58±7.588)%;AMI组(81.41±6.851)%],(P<0.01)。结论血浆vWF-cp活性降低在ACS血栓形成中可能起重要作用。
Objective To observe the changes of plasma yon Willebrand factor-cleaving protease （vWF- cp） in patients with acute coronary syndrome（ACS）. Methods ACS included unstable angina pectoris（UAP） and acute myocardial infarction （AMI）, 17 patients presenting with UAP and 17 patients presenting with AMI as well as 17 patients presenting with stable angina pectoris （SAP） were studied and 17 healthy volunteers served as control. Coronary angiography was performed in all patients and normal control persons. The plasma vWF-ep activity was measured by residual collagen binding activity （R-CBA）. Results （1）The plasma vWF-cp activity was significantly lower in patients with ACS [ UAP （ 53.17 ± 11.72 ） %, AMI （46.47 ± 11.81 ） % ] than those with SAP [ （ 77.00 ± 10.42）%] （P〈0.01） and normal controls[（80.79±17.25）%] （P〈0.01）, but no difference between the latter two groups （ P〈0.05 ） .（2）There was no difference in plasma level of vWF-cp between UAP [ UAP （ 53.17 ± 11.72 ） % ] and AMI [ （46.47±11.81 ）% ]patients when admitted（P〈0.05）. Plasma level of vWF-cp activity in ACS patients when admitted was marked lower than that when recovered [ UAP （79.58 ±7.588 ） %, AMI （ 81.41±6.851 ） % ] （P〈0.01 ）. Conclusion The decreased vWF-cp activity in plasma may play an important role in the thrombosis of ACS.
出处
《中国心血管病研究》
CAS
2007年第9期662-664,共3页
Chinese Journal of Cardiovascular Research
