摘要
目的观察补肾壮骨中药对模拟失重状态下大鼠股骨远端松质骨超微结构的改变。方法SPF级雄性SD大鼠15只,随机等分为3组:A组为自由活动对照组,B组和C组为尾吊模拟失重组,C组大鼠给予补肾壮骨中药灌胃,其他2组灌胃等量生理盐水,实验期28d。利用扫描电镜对大鼠股骨远端松质骨的结构进行观察。结果B组较A组大鼠的骨小梁变细,断裂,数量减少,微损伤增多;C组较B组大鼠骨小梁数量增加,骨吸收面减少,胶原纤维排列规律、整齐。结论补肾壮骨中药能够对模拟失重状态下大鼠股骨远端松质骨的骨微结构产生有益影响。
Objective To observe the effect of Chinese herbal medicine for supplementing Shen and strengthening the bone on distal femoral trabecular ultrastructure of male rats subjected to simulated weightlessness. Methods Fifteen male SD rats were randomized equally into 3 groups, including a control group （group A, in which the rats were allowed free movement） and two simulated weightlessness （via tail suspension） groups （group B and C）. The rats in group C were treated with the commercially available Chinese herbal preparation, and those in the other two groups received normal saline at the same dose, for a treatment course of 28 days. Observation oftrabeculae was performed with scanning electron microscopy. Results In group B, the trabeculae of the femur became thinner, fragile, discontinuous with reduced quantity as compared with those in group A. The rats in group C had greater number of the trabeculae than those in group B. Resorption surface decreased and the collagenous fiber were much more regular in group B. Conclusion The Chinese herbal medicine may produce beneficial effect on bone microstructure of rats subjected to simulated weightlessness.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第9期1458-1460,共3页
Journal of Southern Medical University
关键词
模拟失重
补肾壮骨
中药
扫描电镜
simulated weightlessness
Chinese herbs
scanning electron microscopy
