摘要
对急性阻塞性黄疸兔模型的马尿酸合成试验（HAT）和反映肝脏能量代谢情况的能荷、线粒体氧化磷酸化率等进行了研究。结果显示：在急性阻塞性黄疸时，能荷（0．72±0.02）和线粒体氧化磷酸化率（38.3±2．4）分别与对照组（0．81±0．01和62．1±5．1）比较，均下降明显（P均<0．001）。HAT（32．7±17．6mg／h）与对照组（98.4±32．0mg／h）相比也明显下降（P＜0．001）；且HAT和能荷的相关系数为0．786。实验结果提示：HAT可作为反映肝脏能量代谢的可靠指标。
Hippuric acid test (HAT) and hepatic energy metabolism and mitochondrial oxidativephosphorylation activity in rabbit with acute obstractive jaundice was studied. The result showed thatthe HAT values were decreased from 98. 4±32. 0mg/h to 32. 7±17. 6mg/h (P<0. 001 ), energy charge(EC)decreased from 0. 81 ± 0. 01 to 0. 72 ± 0. 02(P< 0. 001 ),and phosphorylation rate (PR ) decreasedfrom 62. 1 ± 5. 1 to 38. 3 ± 2. 4 (P<0. 001 ). Correlation coefficients between HAT and EC was 0. 786,(P<0. 001 ). This result suggests that HAT can be used as an indicator of hepatic energy metabolismstatus in acute obstructive jaundice.
基金
日本文部省资助
关键词
马尿酸试验
阻塞性黄疸
能量代谢
肝脏
Hippuric acid test Obstructive jaundice Energy metabolism Rabbit
