摘要
目的评价拉莫三嗪对癫癎患者认知功能以及生活质量的影响。方法对91例新诊断的癫癎患者给予拉莫三嗪治疗,并在用药前及用药16周后进行认知功能评定及生活质量调查。认知功能评定工具包括听觉词语测验、逻辑记忆测验、数字符号转换测验、Stroop 字色干扰测验、连线测验、言语流畅性测验、韦氏积木测验、数字广度测验及 Boston 命名测验;生活质量调查采用患者生活质量评定量表-31(QOLIE-31)。结果癫癎患者应用拉莫三嗪治疗16周后与用药前比较,各项得分均有提高,其中以即刻与延迟词语记忆、情景记忆、执行功能、空间知觉能力以及言语命名功能方面改善显著。生活质量方面,QOLIE-31量表的7个测评方面及1个总体健康评价中,6项分值在用药后较用药前有所提高,其中"对癫癎的担心"(38.81±16.06,16周后45.68±15.18,P<0.01)、"总体生活质量"(59.12±13.50,16周后64.99±13.33,P<0.01)、"社会功能"(64.59±25.14,16周后69.41±22.70,P<0.05)以及"总体自身健康评价"(71.18±13.73,16周后76.75±11.30,P<0.01)4项的得分差异有统计学意义。结论拉莫三嗪单药治疗新诊断癫癎患者可在短期内改善其认知功能,并提高生活质量。
Objective To explore the effects of lamotrigine on the cognitive function and the quality of life in epilepsy patients. Methods This was a prospective study and 91 newly diagnosed epilepsy patients were enrolled. The neuropsychological tests score and the quality of life in epilepsy inventory （ QOLIE-31 ） were obtained before and after the treatment with lamotrigine. A battery of neuropsychological tests comprised the auditory verbal learning test （ AVLT）, the logical memory test （ LMT）, the digital symbol test （ DST）, the stroop color word test （ SCWT）, the trail making test （ TMT）, the verbal fluency test （ VFT）, the WAIS block design test （WBDT）, the WAIS digital span test （WDST） and the Boston naming test （BNT）. Results The repeated assessments in the patients taking lamotrigine were associated with significant improvements in many domains. The greatest changes were observed in the immediate and delayed recall of AVLT, DST, the time consuming of SCWT card C and TMT test A and B, the immediate and delayed recall of LMT, VFT, WBDT and BNT. For the quality of life, significant improvements were recorded in the fields of the seizure worry （ 38. 81 ± 16. 06 vs 45.68± 15.18） , the overall quality of life （ 59. 12 ± 13.50 vs 64. 99 ±13.33 ） , the social function （ 64. 59 ± 25.14 vs 69.41 ± 22.70 ） and the self-heahh evaluation （71.18 ± 13.73 vs 76. 75 ± 11.30）. Conclusion Improvements of the cognitive function and the quality of life can be observed in the initial period of medication with lamotrigine in epilepsy patients.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2007年第9期630-633,共4页
Chinese Journal of Neurology
关键词
癫痫
三嗪类
认知
生活质量
Epilepsy
Triazines
Cognition
Quality of life
