摘要
目的探讨窄谱中波紫外线(NB-UVB)治疗早期蕈样肉芽肿(MF)的安全性及有效性。方法19例患者中,男9例,女10例;年龄20～71岁,平均42.6岁,经组织病理检查证实为MF早期,临床分期ⅠA～ⅠB 17例,ⅡA 2例。每周NB-UVB照射2～3次,随访1～18个月。结果13例完全缓解,5例部分缓解,1例无缓解。平均照射次数25.9次,平均累积照射剂量25.6 J/cm^2。主要不良反应为红斑、瘙痒和色素沉着,患者均能耐受。结论NB-UVB照射对早期MF疗效确切,不良反应较少。
Objective To evaluate the efficacy and safety of narrow-band UVB （ NB-UVB ） in the treatment of early stage mycosis fungoidcs （ MF ）. Methods Nineteen patients histopathologically diagnosed as early stage MF, including 9 males and 10 females （ aged between 20 - 71 years with an average of 42.63 year ）, wcrc enrolled into this prospective open clinical study. Of them, 17 were at stage Ⅰ, and 2 at stage Ⅱ A. All patients received topical photothcrapy with NB-UVB twice or thrice a week, and followed up for 1-18 months. Results Among the 19 patients, 13 achieved complete response （CR）, 5 achieved partial response （ PR ）, and 1 did not respond. The average radiation frequency was 25.9, and mean accumulated radiation dose 25.6 J/cm^2. Main side effects wcrc crythcma, pruritus and hyperpigmcntation, which wcrc all tolerable. Conclusion NB-UVB is effective for the treatment of early stage MF with fewer side effects.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2007年第9期530-532,共3页
Chinese Journal of Dermatology
关键词
紫外线疗法
真菌病
蕈样
Ultraviolet therapy
Mycosis fungoides
