摘要
概述了肝郁证的病因病机、证治范畴及实质研究进展。设立肝郁证动物模型，选用溶血素、脾淋巴细胞转化率、白细胞介素２为指标，检测实验动物的免疫功能。结果提示，肝郁证模型表现免疫力低下，而疏肝解郁方剂逍遥散对此有一定改善作用。结合精神、心理、神经、内分泌等多方面与肝郁证有关的资料，借助心理神经免疫学的理论，分析认为免疫学异常、免疫力低下是肝郁证的重要发病环节，是神经—内分泌—免疫网络失调的结果。
Animal model is set up,and the experimental study of immunology of the syndrome is carried out.Chosing the immunological form of cellular and molecular level:hemolysin,splenic lymphocyte transformation rate and interleukin(IL—2),the study examines the immune function of experimental animals.The results indicates that the immunologic function of the body with the syndrome is abnormal,and their immunity is low.The prescription Xiao Yao San for regulating the liver and alleviating the stasis has some therapeutic effects.Combining the previous materials of psyohology、nerve、endocrine of the syndrome,resorting to the modern medical model——psychoneuroimmunology(PNI),the study holds the viewpoints that immune abnormity and lowness of immunity are the important pathogenesis of the syndrome,and are the results of disturbance of the Neuroendocrine—immune network (NDIN).We should reinforce the studies for the neuroimmunological essence of liver—stasis syndrome,animal model,mechanism and efffect of regulating the immunity by sorts of prescriptions and medicines.
出处
《山东中医药大学学报》
1997年第1期28-32,共5页
Journal of Shandong University of Traditional Chinese Medicine
关键词
肝郁证
心理
神经
免疫学
逍遥散
Liver—stasis syndrome Immune experiment Psychoneuroimmunology Xiao Yao San
