摘要
目的探讨趋化因子受体CXCR4在乳腺癌组织中的表达及其临床意义。方法用免疫组织化学方法检测45例乳腺癌及10例乳腺纤维腺瘤组织中趋化因子受体CXCR4的表达，并对原位癌与发生转移的癌组织中的CXCR4的表达率进行比较。结果在乳腺癌组织上检测到趋化因子受体CXCR4的表达（表达率为62．2％），其中癌组织发生转移的CXCR4的表达率为69．4％，未发生转移的表达率为33．3％，而乳腺纤维腺瘤组织中未发现CXCR4的表达。结论乳腺癌组织上有趋化因子受体CXCR4的表达，其表达可能在乳腺癌的发生、发展和转移中起重要作用。
Objective To explore the expression of chemokine receptor CXCR4 in breast cancer tissue and its clinical significance. Methods Forty-five cases of breast cancer specimens and ten cases of breast fibroadenoma specimens were analyzed by immunohistochemical staining for CXCR4 expression. The rates of CXCR4 expression were compared between primary and metastastic breast cancer tissue. Results The expression of CXC7R4 was detected in breast cancer （the positive rate was 62.2%）. The CXCR4 expression rate in primary and metastastlc breast cancer tissue was 33.3% and 69.4% respectively, while CXCR4 was not detected in breast fibroadenoma specimens. Conclusion CXCR4 expresses in human breast cancer tissue, and it may play an important role in the occurrence, development and metastasis of human breast cancer.
出处
《国际检验医学杂志》
CAS
2007年第10期888-889,893,共3页
International Journal of Laboratory Medicine
关键词
趋化因子受体
CXCR4
乳腺癌
Chemokine receptor
CXCR4
Breast cancer
Immunohistochemistry stain
