摘要
目的探讨经皮穿刺附睾取精（PESA）结合卵细胞浆内单精子注射（ICSI）治疗梗阻性无精子症的有效性和安全性。方法对48例梗阻性无精子症病人进行PESA。女方常规超促排卵治疗以获取卵子，选择成熟的卵母细胞行ICSI。结果48例病人共接受60个周期的治疗，除1例病人第3个周期行附睾切开取精外，其余均行PESA取精成功。共取卵636个，553个成熟卵子行ICSI，426个卵子正常受精，正常受精率77．0％；获得412个胚胎，卵裂率96．7％；优质胚胎265个，优质胚胎率64．3％。每个治疗周期移植胚胎2～3个，21例获得临床妊娠，周期临床妊娠率为35．0％。结论PESA结合ICSI能有效地治疗梗阻性无精子症引起的男性不育症。
Objective To evaluate the efficacy of intracytoplasmic sperm injection （ICSI） with sperm obtained from percutaneous epididymal sperm aspiration （PESA） for male infertility caused by obstructive azoospermia （OA）. Methods PESA was performed in 48 patients with OA to obtain sperm. Matured Oocytes retrieval under transvaginal ultrasound were selected for ICSI. Results All the couples received 60 cycles of ICSI. PESA was performed successfully in 59 cycles of 48 male patients except one receiving epididymotomy at the third cycle. Of the female, 636 oocytes were retrieved in all cycles, 553 M Ⅱ oocytes were microinjected; 426 oocytes were normally fertilized and the fertilization rate was 77.0%; 412 fertilized oocytes cleaved to embryos and the cleavage rate was 96.7%. 2-3 embryos were replaced into uterus for each transfer cycle. Clinical pregnancy was 21, the per-cycle pregnancy rate was 35.0G. Conclusion PESA combined with ICSI is an effective method to treat male infertility with obstructive azoospermia.
出处
《齐鲁医学杂志》
2007年第6期487-488,490,共3页
Medical Journal of Qilu
关键词
少精子症
卵细胞浆内单精子注射
经皮穿刺附睾取精
oligospermia
intracytoplasmic sperm injection
percutaneous epididymal sperm aspiration
