摘要
目的:就近几年对降钙素受体基因多态性与骨密度相关性方面的研究进行综述。详细地分析了降钙素受体基因突变对骨密度的影响,从而为鉴定骨质疏松高危人群提供依据。资料来源:应用计算机检索Medline、springerlink和ScienceDirect Online数据库1980-01/2007-01期间的相关文章,检索词为"降钙素受体、基因多态性、骨质疏松、骨密度、候选基因"限定文章语言种类为英文。同时计算机检索中国期刊全文数据库1990-01/2007-01期间的相关文章,检索词为"降钙素受体,基因多态性,骨质疏松,骨密度",限定文章语言种类为中文。资料选择:对资料进行初审,选择关于降钙素受体基因多态性与骨密度相关性文献79篇,筛除明显缺少对照的实验研究,并对剩余原文查找全文,排除综述类和重复研究。资料提炼:选择其中有代表性的31篇进行综述,涉及到降钙素和降钙素受体的作用机制及基因多态性、降钙素受体基因多态性与骨密度相关性方面的研究。47篇被排除的文章中,44篇缺少随机对照或重复研究,另3篇是综述。资料综合:对所选文章内容进行总结。对降钙素受体基因多态性与骨密度相关性方面的资料进行概括和评价,对降钙素受体基因型在正常与骨质疏松组进行比较。计算不同基因型在人体测量指标、脊柱及股骨骨密度等方面的差异。通过这些数据分析,降钙素基因多态性在预测骨质疏松方面的潜在价值仍很有争议。结论:分析降钙素受体基因多态性与骨质疏松相关性有很重要的临床价值。对骨量的基因调控方面的研究有几个潜在的价值:通过认证哪些基因对骨质疏松的发病有作用,可能会改善治疗方法,实际上一些候选基因本身成为新治疗的靶点;分子标志在认证个体在骨质疏松发病风险方面的潜在价值同样很重要。降钙素受体基因多态性与骨质疏松相关性的基因研究方面的重要成果会对认证这种疾病的高危人群起到促进作用。
OBJECTIVE： To review and summarize the researches on the association between calcitonin receptor gene polymorphism and bone mineral density, and analyze the effect of calcitonin receptor mutation on bone mineral density in detail, so as to provide evidence for the identification of individuals at risk of osteoporosis. DATA SOURCES： A computer-based online search of Medline, springerlink and ScienceDirect Online was undertaken for relevant English articles published between January 1980 and January 2007 with the keywords of ＂calcitonin receptor, gene polymorphism, osteoporosis, bone mineral density, candidate gene＂. Meanwhile, CNKI was searched for relevant literatures dated from January 1990 to January 2007 with the keywords of ＂calcitonin receptor, gene polymorphism, osteoporosis, bone mineral density＂ in Chinese. STUDY SELECTION： Seventy-nine articles about the relationship between caicitonin receptor gene polymorphism and bone mineral density were selected after first trial. Those obviously lacking of randomized controlled trial, repeated articles and reviews were excluded. The rest full-texts were looked up. DATA EXTRACTION： Thirty-one typical articles were reviewed involving the action mechanism and gene polymorphism of calcitonin and calcitonin receptor, research on correlation between calcitonin receptor gene polymorphism and bone mineral density. Of the 47 excluded articles, 44 were non-randomized or repetitive studies, and the other 3 were reviews. DATA SYNTHESIS： The data about the correlation between calcitonin receptor gene polymorphism and bone mineral density in etiology and pathogenesis were summarized and evaluated. The frequency distribution of calcitonin receptor genotypes in normal and osteoporotic groups was compared. Differences in anthropometric characteristics, spinal and femoral bone mineral density among populations with different calcitonin receptor genotypes were calculated. Based on these data, however, it is still controversial that calcitonin gene polymorphism is of potential value in predicting osteoporosis. CONCLUSION： It is of great clinical significance to analyze the correlation between calcitonin receptor and osteoporosis. Studies on the genetic regulation of bone mass display several potentially useful outcomes： By identifying the genes which contribute to the pathogenesis of osteoporosis, it may be possible to develop improved methods of treatment, and indeed some candidate genes may themselves form new therapeutic targets; Equally important is the potential use of molecular markers in the identification of individuals at risk of osteoporosis. The important outcome of genetic studies in correlation between calcitonin receptor and osteoporosis will improve the identification of patients at risk of this disease.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第41期8345-8348,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
