期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管紧张素Ⅱ及缬沙坦对犬心房肌细胞外向钾通道电流的作用

Effects of Angiotensin Ⅱ and Valsartan on outward potassium channel currents in canine atrial myecytes
原文传递
导出
摘要 目的观察血管紧张素Ⅱ及缬沙坦对犬心房肌细胞外向钾通道电流的作用,探讨其参与房性心律失常的细胞电生理机制。方法急性分离单个犬心房肌细胞,采用全细胞膜片钳方法记录细胞膜快速延迟整流钾电流（Ikr）、缓慢延迟整流钾电流（Iks）、超快速延迟整流钾电流（Ikur）及短暂外向钾电流（Ito）。结果0.5μmol/L AngⅡ可增加Ikr、Iks,抑制Ito,对Ikur无明显影响;5μmol/L缬沙坦对Ikr、Iks、Ikur及Ito均有抑制作用。结论AngⅡ可能通过对外向钾电流的影响促进AF时的AER,缬沙坦作为AT1受体阻滞剂,可改善AF时的AER,对AF有防治作用。 Objective To observe the effects of Angiotensin Ⅱ （Ang Ⅱ ） and Valsartan on outward potassium channel currents in canine atrial myocytes and study the mechanisms of Ang Ⅱ and Valsartan on atrial arrhythmia. Methods Single canine atrial myocyte was isolated and whole-cell configuration of the patch-clamp technique was used to detect Ikr, Iks, Ikur and Ito. Results Ang Ⅱ （0. 5 μmol/L） increased Ikr and Iks respectively. Meanwhile, Ang Ⅱ inhibited Ito, but no effect on Ikur. Valsartan （5μmol/L） inhibited Ikr, Iks, Ikur and Ito respectively. Conclusion Ang Ⅱ may promote atrial electrical remodeling of AF by effects of outward potassium currents. As receptor blockers of Angiotensin Ⅱ , Valsartan can prevent atrial electrical remodeling of AF.
作者 代建军 李广平 李健 许纲 杨万松
机构地区 济宁医学院附属金乡医院心内科 天津医科大学第二医院心脏科
出处 《中国医师杂志》 CAS 2007年第10期1350-1353,共4页 Journal of Chinese Physician
关键词 血管紧张素Ⅱ 缬氨酸/类似物和衍生物 肌细胞 心脏 钾通道 Angiotensin Ⅱ Valine/AA Myocytes, cardiac Potassium channels
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

  • 1Kumagai K, Nakashima H, Urata H, et al. Effects of angiotensin Ⅱ typel receptor antagonist on electrical and structural remodeling in atrial fibrillation. J Am Coil Cardiol, 2003, 41(12) : 2197-2204.
  • 2Boldt A, Wetzel U, Weigl J, et al. Expression of angiotensin Ⅱ tyre 2 receptors in human left and right atrial tissue in atrial fibrillation with and without underlying mitral valvedisease. J Am Coil Cardiol, 2003, 42 (10) :1785-1792.
  • 3Li D, Melnyk P, Feng J, et al. The effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation, 2000, 101: 2631-2639.
  • 4Cha TJ, Ehrlich JR, Zhang L, et al. Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure. Circulation, 2004, 110(12) : 1520-1526.
  • 5Zankov DP, Omatsu-Kanbe M, Isono T, et al. Angiotensin I[ Potentiates the Slow Component of Delayed Rectifier K + Current via the AT1 Receptor in Guinea Pig Atrial Myocytes. Circulation, 2006; 113:1278-1286.
  • 6Daleau P, Turgeon J. Angiotensin Ⅱ modulates the delayed rectifier potassium current of guinea pig ventricular myocytes. Ptlugers Arch, 1994, 427:553-555.
  • 7Gassanov N, Brandt MC, Michels G, et al. Angiotensin Ⅱ induced changes of calcium sparks and ionic currents in human atrial myocytes: potential roles for early remodeling in atrial fibrillation. Cell Calcium, 2006,39(2) :175-186.
  • 8张殿新,黄岚,王海昌,张荣庆,程何祥,刘兵,郭文怡,李伟杰,秦涛.血管紧张素Ⅱ对人心房肌细胞膜钾钙离子电流的作用[J].中国心脏起搏与心电生理杂志,2005,19(3):179-181. 被引量：5
  • 9Chen YJ, Chen YC, Tai CT, et al. Angiotensin Ⅱ and angiotensin Ⅱ receptor blocker modulate the arrhythmogenic activing of pulmonary veins. Br J Phar-macol, 2006, 147:12-22.
  • 10Caballero R, Delpon E, Valenzuela C, et al. Losartan and its metabolite E3174 modify cardiac delayed rectifier Kt currents. Circulation, 2000, 101 : 1199-1205.

二级参考文献10

  • 1Pedersen OD, Bagger H, Kober L, et al. Trandolapril reduces the incidence of atrial fibrillation after acute myocardial infarction in patients with left ventricular dysfunction [J]. Circulation, 1999, 100(4):376.
  • 2Li D, Shinagawa K, Pang L, el al. Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in clogs with ventricular tachypacing-induced congestive heart failure[ J ]. Circulation ,2001,104( 21 ) :2608.
  • 3Kumagai K, Nakashima H, Urata H, et al. Effects of angiotensin Ⅱ type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation[J]. J Am Coll Cardiol, 2003,41(12):2197.
  • 4Boldt A, Wetzel U, Weigl J, et al. Expression of angiotensin Ⅱ receptors in human left and right atrial tissue in atrial fibrillation with and without underlying mitral valve disease[J]. J Am Coll Cardiol,2003,42(10):1785.
  • 5Madrid AH, Bueno MG, Rebollo JM, et al. Use of irbesartan to maintain sinus rhvthm in patients with long-lasting persistent atrial fibrillation: a prospective and randomized study [J]. Circulation,2002,106(3):331.
  • 6Ichiyanagi O, Ishii K, Endoh M, Angiotensin Ⅱ increases L-type Ca^2+ current in gramicidin D-perforated adult rabbit ventricular myocytes: comparison with conventional patch-clamp method[J].Pflugers Arch, 2002,444 ( 1-2 ) : 107.
  • 7Caballero R, Gomez R, Moreno I, et al. Interaction of angiotensin Ⅱwith the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current[J].Cardinvasc Res, 2004,62(1) :869.
  • 8杨向军,蒋文平.AngⅡ受体对内向整流性钾流的影响[J].苏州医学院学报,2000,20(4):314-316. 被引量：4
  • 9张荣庆,梁延春,周更须,程何祥,贾国良,蔡振杰.国人单个心房肌细胞的分离及活性鉴定[J].第四军医大学学报,2001,22(2):188-190. 被引量：8
  • 10吴书林,薛玉梅,钱卫民,邓春玉,陈纯波.心房颤动患者心房肌细胞离子重塑及缬沙坦的干预研究[J].中华心血管病杂志,2004,32(3):197-201. 被引量：36

共引文献4

中国医师杂志
2007年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部