2Wolf G, Ziyadeh F N. Molecular mechanisms of diabetic renal hypertrophy[J]. Kidney Int, 1999, 56(2): 393-405.
3Ziyadeh F N, Han D C. Involvement of transforming growth factor-beta and its receptors in the pathogenesis of diabetic nephrology[J]. Kidney Int, 1997, 60(Suppl): 7-11.
4Ha S W, Kim H J, Bae J S, et al. Elevation of urinary betaig-h3, transforming growth factor-beta induced protein in patients with type2 diabetes and nephropathy [J]. Diabetes Res Clin Pract, 2004, 65(2): 167-173.
5Hoshi S, Shu Y, Yoshida F, et al. Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats [J]. Lab Invest, 2002, 82(1): 25-35.
6Ina K, Kitamura H, Tatsukawa S, et al. Transformation of interstitial fibroblasts and tubulointerstitial fibrosis in diabetic nephropathy[J]. Med Electron Mierose, 2002, 35(2): 87-96.
7Li J H, Zhu H J, Huang X R, et al. Smad 7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad 2 aetivation[J]. J AmSoe Nephrol, 2002, 13(6): 1464-1472.
8Nakagawa H, Sasahara M. Immunohistochemical characterization of glomerular PDGF-β-chain and PDGF beta-receptor expression in diabetic rats[J]. Diabetes Res Clin Pract, 2000, 48(2): 87-98.
9Langham R G, Kelly D J, Maguire J, et al. Over-expression of platelet-derived growth factor in human diabetic nephropathy[J]. Nephrol Dial Transplant, 2003, 18(7): 1392-1395.
10Fraser D, Wakefield L, Phillips A. Independant regulation of transforming growth factor-beta1 transcription and translation by glucose and plateletderrived growth factor[J]. Am J Pathol, 2002, 161(3): 1039-1049.
3Medina EA, Erichson KL, Stanhope KL, et al. Evidence that tumor necrosis factor-alpha-induced hyperinsuline mia prevents decreases of circulating leptin during fasting in rat [J]. Metabolism, 2002, 51:1104-1110.
4Ford ES. Body mass index: Diabetes. And c-reactive protein among US adults (4). Diabetes Care,1999, 22:1971-1977.
5Andreas F, Ralph D, JR, et al. lnflamation and microalbuminuria in nondiabetes and type2 diabetes: The Insulin Resistance Atherosclerosis Study (4). Kidney Intemational, 2000,58:1703-1710.
6王海燕 等.肾脏病学:第2版[M].北京:人民卫生出版社,1997.1385—1387.
7Lechleitner M, Koch T, Herold M, et al. Tumor necrosis factor alpha plasma level in patients with type 1 diabetes mellitus and its association with glycaemic control and card-iovascular risk factors[J] .J Intern Med,2000,248:67-76.
8John C P, Gary D C, Stephen M T, et al. Plasma interleu-kin 6, tumor necrosis factor α and blood cytokine production in type 2 diabetes[J]. Life Sci,2000,67:291-300.
9Pfeiffer A, Janott J, Mohlig M, et al. Circulating tumor ne-crosis factor α is elevated in male but not in female patients with type Ⅱ diabetes mellitus [ J]. Horm Metab Res, 1997,29:111-114.
10Hellmich B, Schellner M, Schatz H, et al. Activation of transforming growth factor β in diabetic kidney disease[J].Metabolism, 2000,49: 355-359.