摘要
应用生化法检测不吸烟的特发性肺纤维化患者１０例及正常对照者６例支气管肺泡灌洗液和血中谷胱甘肽水平，判断氧化剂—抗氧化剂失衡与肺纤维化的关系。结果：支气管肺泡灌洗液中谷胱甘肽水平明显低于正常对照组（Ｐ＜０．０５）；血中谷胱甘肽含量两组无明显差别。
To determine the relationship between oxidant antioxidant imbalance and pulmonary fibrosis,we measured the level of glutathione in bronchoalveolar lavage fluid and blood in 10 nonsmoking patients with idiopathic pulmonary fibrosis and 6 controls. The results:The glutathione concentration in lavage fluid of patients with idiopathic pulmonary fibrosis decreased obviously as compared with that in the controls (P<0.05). No significant difference was found between the patients and the controls in blood level of glutathione. This suggested glutathione might result in oxidant antioxidant imbalance and play a role in pulmonary fibrosis.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1997年第3期261-263,共3页
Journal of China Medical University
关键词
肺纤维化
谷胱甘肽
支气管肺泡
灌洗液
idiopathic pulmonary fibrosis
glutathione
bronchoalveolar lavage fluid
