摘要
通过直接酰胺化反应,以马来酸酐本体改性聚乳酸（MPLA）和氨基封端聚乙二醇（H2N-PEG-NH2）为原料,合成了聚乙二醇本体改性聚乳酸（PPLA）.通过红外、核磁共振技术对改性聚合物的结构进行了表征;采用FITC标记牛血清白蛋白（FITC-BSA）为模型蛋白质,测试了聚合物对蛋白质的非特异性吸附;利用吸水率表征了聚合物的亲水性;利用聚合物在12周降解过程中pH值、失重率的变化评价了它们的降解特性.结果表明：H2N-PEG-NH2已成功接枝到MPLA上;与聚乳酸（PLA）、MPLA相比,PPLA明显降低了对FITC-BSA的吸附;其亲水性和降解性增加.预计该材料将是一种更适合组织工程和药物缓释应用的聚乳酸类可降解材料.
A new poly（ethylene glycol） （PEG） graft poly（D, L-lactic acid） （PLA） was synthesized using maleic anhydride graft PLA （MPLA） and amine terminated PEG （H2N-PEG-N2H） as raw materials. Its structure was confirmed via FTIR and 1H-NMR. The anti-non-specific protein adsorption property was visualized by fluorescent microscopic image with Fluorescein 5-isothiocyanate （FITC） conjugated bovine serum albumin （FITC-BSA）. The hydrophility was tested through water uptake. Degradation was investigated by pH change and weight loss during 12 weeks. The results showed that H2N- PEG-N2H was successfully grafted onto MPLA and formed PPLA. Compared with MPLA and PLA, PPLA had prominent properties of decreasing BSA adsorption and increased hydrophility and degradability, all of which may lead to its potential applications in drug delivery and tissue engineering.
出处
《高技术通讯》
CAS
CSCD
北大核心
2007年第7期736-741,共6页
Chinese High Technology Letters
基金
国家自然科学基金（30300084）和国家＂111计划--生物力学与组织修复工程＂资助项目.
关键词
聚乙二醇
聚乳酸
接枝
亲水性
降解性
poly（ethylene glycol）, poly （D,L-lactic acid）, graft, hydrophility, degradability
