摘要
目的:探讨短暂性脑缺血发作(TIA)患者C反应蛋白(CRP)和血浆D-二聚体(D-dimer,D-D)水平的变化。方法:99例TIA患者按病程划分为A、B、C三组,所有病例在起病24h内检测血清CRP和D-D的水平,观察72h内头CT或MRI后与正常对照组进行比较,结果进行组间比较。结果:TIA患者血清CRP[A组(11.8±1.4)mg/L,B组(18.4±1.3)mg/L,C组(26.8±1.4)mg/L]和D-D[A组(0.57±0.15)mg/L,B组(1.03±0.19)mg/L,C组(1.38±0.22)mg/L]的水平明显高于正常对照组[CRP(5.0±1.2)mg/L,D-D(0.26±0.11)mg/L](P<0.01),B、C组CRP和D-D的水平均高于A组(P<0.01),而B、C两组之间比较差异也有显著性(P<0.05),TIA各组CRP和D-D水平之间的相关性分析显示CRP与D-D水平均呈显著正相关A组r=0.723,P<0.01;B组r=0.761,P<0.01;C组r=0.768,P<0.01。结论:(1)CRP是D-D水平升高的主要相关因素;(2)CRP和D-D水平的升高可能是TIA患者的危险因素;(3)CRP和D-D水平的升高可以对TIA患者的诊断、治疗和估计预后提供较可靠的实验室指标。
Objective：To investigate the fluctuation of Serum CRP and Plasma D-dimer Levels in patients with transient cerebral ischemic attack（TCIA）. Methods：99 patients with TCIA were divided into three groups of A, B, C. All cases were measured within 24 hours with CRP and D-dimer. Head CT or MRI were carried out within 72 hours,and compared with control group, and compared between different groups of TCIA. Results： The levels of serum CRP [A group （11.8±1.4） mg/L,B group （18.4±1.3） mg/L,C group （26.8± 1.4） mg/L] and plasma D-dimer with TCIA（A group （0.57±0.15） mg/L,B group （1.03±0.19） mg/L,C group （1.38±0.22） mg/L] were higher than control group [CRP（5.0±1. 2） mg/L,D-D（0. 26±0.11） mg/L]（P〈0. 01） ,The levels of serum CRP and plasma D-dimer of B and C groups were higher than A group（P〈0. 01） ,and the level was different obviously between B and C group（P〈0. 05）. The correlative analysis of all groups with TCIA demonstrated that plasma D-dimer had obvious positive relationship with CRP. Conclusion： （1）CRP is the major factor about the rise of D-dimer; （2）The increase of the levels of CRP and D-dimer is dangerous factors for the patients with TIA;（3） The increase of the levels of levels of CRP and D-dimer can provide a reliable index of laboratory observation of diagnosis,treatment and estimating prognosis.
出处
《中国误诊学杂志》
CAS
2007年第25期5959-5961,共3页
Chinese Journal of Misdiagnostics
