摘要
目的研究弯斑蛸不同组织提取的3种多糖对免疫抑制小鼠的调节作用。方法腹腔注射环磷酰胺和氢化可的松构建2种免疫抑制模型；测定脾脏、胸腺重量并计算脏器指数；用多项目自动血球计数仪进行白细胞等计数。结果在20-80mg·kg^-1剂量范围内，弯斑蛸3种多糖能对抗分别由环磷酰胺和氢化可的松引起的小鼠脾萎缩和胸腺萎缩，增加脾和胸腺重量；明显拮抗二者引起的白细胞减少等作用。结论弯斑蛸多糖能增强免疫抑制小鼠的非特异性免疫功能。
Objective To study the immunoregulation effect of three kinds of polysaccharides extracted from different tissues of Octopus dollfusi on immunosuppression mice. Methods Two kinds of immunosuppression mice models were built by ip, cyclophosphamide （CY） and sc. hydrocortisone （HC）, respectively. The spleen and thymus were weighed and the index of the immune organs was calculated. The white blood cells were counted by automated hematologic analyzer. Results In certain concentrations （20~80 mg · kg^-1 ）, the three kinds of polysaccharides could antagonize the atrophy of spleen and thymus caused by CY and HC, and increase the weight of spleen and thymus; The polysaccharides could protect against leukocytopenia induced by CY and HC, and especially in low and middle dose. Conclusion The results suggested that three kinds of polysaccharides extracted from Octopus dollfusi have potent enhancement effect on non-specific immunity for the immunosuppression mice.
出处
《中国海洋药物》
CAS
CSCD
2007年第5期29-33,共5页
Chinese Journal of Marine Drugs
基金
广东省科技厅社会攻关项目(No.2003C32805)
关键词
弯斑蛸多糖
免疫抑制
脏器指数
白细胞
polysaccharide from Octopus dollfusi
immunosuppression
index of immune organs
white blood cell
