摘要
成年雄性Ｗｉｓｔａｒ大鼠随机分为５组：正常对照组；高脂（ＨＦＤ）对照组；ＨＦＤ＋Ｓｅ（０．５ｍｇ／ｋｇ）组；ＨＦＤ＋ＶＥ（０．６ｇ／ｋｇ）组；ＨＦＤ＋Ｓｅ（０．５ｍｇ／ｋｇ）＋ＶＥ（０．６ｇ／ｋｇ）组。观察１２周。结果表明：ＨＦＤ＋Ｓｅ组、ＨＦＤ＋ＶＥ组及ＨＦＤ＋Ｓｅ＋ＶＥ组血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）及低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）水平皆明显低于ＨＦＤ组，而血清高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）水平明显高于ＨＦＤ组；ＨＦＤ＋Ｓｅ组、ＨＦＤ＋ＶＥ组及ＨＦＤ＋Ｓｅ＋ＶＥ组三组血清脂质过氧化物（ＬＰＯ）水平皆明显低于ＨＦＤ组，而血浆超氧化物歧化酶（ＳＯＤ）活力明显高于ＨＦＤ组；补Ｓｅ组（ＨＦＤ＋Ｓｅ组及ＨＦＤ＋Ｓｅ＋ＶＥ组）血浆谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力明显高于ＨＦＤ组，而ＨＦＤ＋ＶＥ组血浆ＧＳＨ－Ｐｘ活力与ＨＦＤ组无显著性差异；肝脏病理检查结果，ＨＦＤ＋Ｓｅ组、ＨＦＤ＋ＶＥ组及ＨＦＤ＋Ｓｅ＋ＶＥ组肝脏脂变明显轻于ＨＦＤ组；其中ＨＦＤ＋Ｓｅ＋ＶＥ组效果最显著。结果提示，Ｓｅ和／或ＶＥ有调节血脂代谢、阻止脂肪肝形成及提高机体抗氧化能力的作用，对高脂血症有一定的预防作用。
The effects of selenium (Se)and/or vitamin E (VE) supplements in the standard high fat diet (HFD) on serum lipids and lipoperoxides were investigated in rats during a period of 12 weeks. Adult male Wistar rats were randomly divided into 5 groups: Control group, High fat Diet (HFD) group, HFD+Se (0.5mg/kg), HFD+VE(0.6g/kg) and HFD+Se(0.5mg/kg)+VE(0.6g/kg) respectively. The results showed that serum concentrations of TC,TG and LDL C were lower significantly and HDL C was higher in rats fed with Se and/or VE in comparison with those in HFD group respectively. Levels of serum LPO in groups of HFD+Se, HFD+VE and HFD+Se+VE were much lower than that in HFD group. Meanwhile, the activity of SOD in groups of HFD+Se, HFD+VE and HFD+Se+VE was markedly higher than that in HFD group. The activity of plasma GSH Px in groups supplemented with Se was much higher. Moreover, hepatic histopathological examination also indicated Se and/or VE had lipotropic effects in ameliorating the development of fatty liver induced by HFD. All the above results showed that the combined effect of Se+VE was better than that of Se or VE respectively. It revealed that Se and/or VE could modulate liver and serum lipids metabolism, and were beneficial in attenuating the ill effect of hyperlipidemia such as fatty liver, elevations of TC, TG, LDL C and LPO etc..
出处
《营养学报》
CAS
CSCD
北大核心
1997年第1期16-22,共7页
Acta Nutrimenta Sinica
关键词
硒
维生素E
高脂血症
血脂
脂质过氧化
selenium vitamin E hyperlipidemia serum lipids lipoid peroxide(LPO)
