摘要
目的:探讨血清TBA测定对急性、慢性肝炎诊断的临床应用价值。方法:以循环酶动力学法测量了96例健康对照组、117例非肝病患者、188例急性、慢性肝炎患者血清TBA水平;以健康对照组X+S的99%可信限确定上限值评估其诊断效能。结果:血清TBA水平健康对照组与非肝病患者分别为5.34±29.28umol/L,与健康时照组差异有非常显著意义(p<0.01);慢性肝炎随病情加重而逐渐升高,至重症肝炎达高峰(结果见表1)各型间差异有非常显著意义(F=60.01,P<0.01)。效能评估诊断特异性为97.44%(114/117),敏感性为90.43%(170/188)。相关性分析显示血清TBA与Tbil、ALT和AST呈正相关,且差异有非常显著意义(r=5032,0.2204和0.2900,P<0.05)。结论:血清TBA测定能较敏感和特异地反应肝脏功能状况,对于急性、慢性肝炎的诊断及其病情判断具有重要的参考价值。
Objective To investigate the clinical application value of serum TBA concentration of serum TBA in 96 cases of healthy controls, 117 cases of nonhepatosis and 188 cases of acute and chronic hepatitis was determined by cyclic enzyme kinetic method. The 99% standard of x＋s of controls was chosen to define reference high valus to evaluate Diagnostic efficiency. Results serum TBA level in healthy controls and in non-hepatosis was 5.34±3.74 umol/L and 5.06±2.87umol/L, there was no statistical difference （P〉0.06）. Acute hepatitis level increased significantly to 34.51±29.28umol/L （P〈0.01）. Chronic hepatitis level of various type increased obviously with pathology degree being severe （tablel）（F=60.08,P〈0.01）,Efficiency estimated that specificity was 97.44%（114/117） and sensitivity was 90.43%（170/188）. Correlation coefficients between serum TBA and Tbil, ALT, AST was a positive correlation （r=-0.5032,0.2204,0.2900,Pall〈0.01）, and GGT was no correlation （r=0.1216,P〉0.05）, Conclusion serum TBA can refleet The hepatic function sensitively and specifically, there was important reference value for diagnosis and estimation pathology of acute and chronic hepatitis.
出处
《实用医技杂志》
2007年第22期3089-3090,共2页
Journal of Practical Medical Techniques
关键词
血清TBA
肝炎
急性
慢性
循环酶动力学法
Serum YTBA
Hepatitis, acute, chronic
cyclic enzyme kinetic method
