摘要
目的:通过对Runx3蛋白在胃粘膜不同病变组织中的表达检测,探讨胃粘膜不同病变组织中Runx3蛋白表达的情况。方法:利用免疫组化法(S-P)检测178例胃癌高危人群胃粘膜活检标本及63例胃癌组织标本中Runx3蛋白的表达情况。结果:1178例胃粘膜组织中,Runx3蛋白在102例浅表性胃炎(CSG)中的阳性表达率为81.37%,在76例萎缩性胃炎(CAG)中的阳性表达率为72.37%,在伴有肠化生(IM)的60例中的阳性率为61.67%,在伴有异型增生(DYS)的9例中阳性表达率为55.55%,在胃癌(GC)中的表达率为41.26%。在CSG中的表达率最高,在胃癌表达率最低。2在63例胃癌中,Runx3蛋白在高分化腺癌、中分化腺癌、低分化腺癌中表达率分别是55.56%、40.00%、27.78%。结论:Runx3蛋白在慢性胃炎和伴肠化生中的表达较胃癌中高。说明Runx3蛋白参与胃癌的发生过程,可能是胃癌发生过程中的关键性基因。
Objective： To investigate the expression of Runx3 protein in the different pathological tissue of gastric mucosa. Methods： The immunohistochemical staining technique （S-P method） was used to detect the expressions of Runx3 in 178 specimens from the population ar gastric cancer risk and 63 specimens of gastric cancer. Results：①The protein expression rate of Runx3 in CS（;, CAG, IM, DYS, GC were 81.37%, 72.37%,61.67% , 55.55% and 41.26% respectively, The difference between CAG,CSG,IM and GC was significant. There was no difference between DYS and GC. ② In 63 cases of gastric cancer, the expression rate of Runx3 in well differentiated, moderately differentiated and poorly differentiated carcinoma was 55. 56%, 40. 00%, 27. 78% respectively. There was no difference between these groups. Conclusion： The protein expression of Runx3 is much higher in CSG and IM, So it may play an important role in carcinogenesis of gastric cancer.
出处
《陕西医学杂志》
CAS
北大核心
2007年第11期1492-1494,共3页
Shaanxi Medical Journal
