摘要
目的了解儿童白血病发生医院感染的临床特点,探讨其防治措施。方法回顾性分析133例急性白血病患儿发生医院感染的特点。总结医院感染与病程阶段、住院天数的关系及感染部位、感染率,并进行统计学处理。结果医院感染率为53.4%（71/133例）。其中急性淋巴细胞白血病与急性非淋巴细胞白血病例次感染率有显著性差异（P〈0.05）;住院第1-3次组医院感染例次高于其他组（Pa〈0.05）,住院天数为1-7d组医院感染例次低于其他组（Pa〈0.05）;复发与未复发组人均医院感染例次无显著性差异（P〈0.05）;败血症以革兰阴性杆菌为主,药敏结果显示普遍敏感的药物为阿米卡星、哌拉西林/他佐巴坦。结论急性白血病患儿医院感染发生率高,医院感染发生与白血病类型、病程阶段、住院天数有关;与预后无关,败血症以革兰阴性杆菌为主。
Objective To explore the clinical characteristics of nosocomial infection in children with acute leukemia and the strategy of prevention and treatment. Methods One hundred and thirty - three cases of nosocomial infection in children with acute leukemia were analyzed by retrospective study. The relationship between nosocomial infection and stage of leukemia, hospitalization duration, and the rate of infection were investigated. Results Nosocomial infection rate was 53.4% （71/133 cases）, significant difference of infection rate between acute lymphoblastic leukemia and nonlymphoblastic leukemia group was found （ P 〈 0.05 ）. The nosocomial infection cases of the first 3 hospitalizations group were more than those of other groups（ Pa 〈 0.05 ）, and the nosocomial infection cases of hospitalizion duration within 7 days group were more than those of other groups（ Pa 〈0.05 ）. There was no significant difference in number of nosocomial infection case per patient between relapse and nonrelapse groups （ P 〉 0.05 ）. The main pathogens of septicaemia were gram negative bacilli, and they were generally sensitive to Amicacin and Pi-peracillin/ tazobactam. Conclusions Children with acute leukemia have high nosocomial infection rate. The occurrence of nosocomial infection was related to the type and stage of leukemia and hospitalization duration but not to the prognosis. The main pathogens of septicaemia were gram negative bacilli.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第22期1707-1708,共2页
Journal of Applied Clinical Pediatrics
关键词
儿童
白血病
医院感染
child
leukemia
nosocomial infection
