摘要
目的：探讨慢性肝病的病变机制。方法：应用免疫组化检测人肝组织ＴＧＦ－α与ＰＣＮＡ的表达，同时测血清ＡＦＰ。结果：ＴＧＦ－α的表达在ＣＡＨ－Ｂ，ＬＣ．ＨＣＣ肝组织两两比较差异无显著性（Ｐ＞０．０６），ＰＣＮＡ的表达在ＣＡＨ－Ｂ与ＨＣＣ组差异无显著性（Ｐ＞０．０５）．但分别与ＬＣ组相比差异有显著性（Ｐ＜０．０５）；血清ＡＦＰ值＞２０μｇ／Ｌ例数在ＣＡＨ－Ｂ与ＨＣＣ组间差异无显著性（Ｐ＞０．０５），分别与ＬＣ组比较差异有显著性（Ｐ＜０．０５），正常肝组织上述各指标皆阴性。结论：ＴＧＦ－α能诱导肝细胞增殖分化，但可被某些因子抑制，致肝组织呈现不同的病理变化。有ＰＣＮＡ表达者其相应血清中ＡＦＰ明显升高。
Objective: To study the mechanism of pathological changes in chronic liver diseases. Methods: 54 liver tissue samples used immunohistochemical method to determine TGF-α and PCNA, and serum AFP was measured simultaneously. Results: Expression of TGF-o and PCNA were found in CAH-B . LC. HCC groups, for TGF-α there was no statistical difference between these groups (P>0.05): neither for PGNA, between CAH-B and HCC (P>0.05), but statistical difference was present between CAH-B and LC, and HCC and LC, respectively (P<0.05). Also, there was no statistical difference in serum AFP more than 20μg/L between CAH-B and HCC (P>0.05), butter was significant between CAH-B and LC (P<0.05), and HCC and LC (P<0.05). Conclusions: TGF-α can induce proliferation and differentiation of hepatocytes, but can be inhibited by some factors . This is why liver tissue showing varying pathologic changes . In patients with PCNA expression, the serum AFP elevates accordingly.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1997年第3期135-137,共3页
Chinese Journal of Digestion
关键词
转化生长因子Α
增殖细胞核抗原
肝组织
HBSAG
Transforming growth factor alpha Proliferating cell nuclear antigen α-fetoprotein Liver
